نتایج جستجو برای: kif1b

تعداد نتایج: 71  

Journal: :Cell 2001
Chunjie Zhao Junko Takita Yosuke Tanaka Mitsutoshi Setou Terunaga Nakagawa Sen Takeda Hong Wei Yang Sumio Terada Takao Nakata Yosuke Takei Masaaki Saito Shoji Tsuji Yasuhide Hayashi Nobutaka Hirokawa

The kinesin superfamily motor protein KIF1B has been shown to transport mitochondria. Here, we describe an isoform of KIF1B, KIF1Bbeta, that is distinct from KIF1B in its cargo binding domain. KIF1B knockout mice die at birth from apnea due to nervous system defects. Death of knockout neurons in culture can be rescued by expression of the beta isoform. The KIF1B heterozygotes have a defect in t...

2002
Hyejung Mok Hyewon Shin Seho Kim Jae-Ran Lee Jiyoung Yoon Eunjoon Kim

Mutation in KIF1B, a kinesin superfamily motor protein, causes a peripheral neuropathy known as Charcot–Marie–Tooth disease type 2A (CMT2A). Little is known, however, about how a defective KIF1B gene leads to CMT2A. Here we report that KIF1B , one of the two splice variants of KIF1B, directly interacts through its C-terminal postsynaptic density-95 (PSD-95)/ discs large/zona occludens (PDZ) dom...

Journal: :Oncology reports 2016
Songyu Chen Mingzhi Han Weiliang Chen Ying He Bin Huang Peng Zhao Qibing Huang Liang Gao Xun Qu Xingang Li

Malignant glioma is notorious for its aggressiveness and poor prognosis, and the invasiveness of glioma cells is the major obstacle. Accumulating evidence indicates that kinesin superfamily proteins (KIFs) may play key roles in tumor invasiveness, but the mechanisms remained unresolved. Our previous study demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) was involved in Kines...

2014
Elisa Vitiello Jorge G. Ferreira Helder Maiato Maria S. Balda Karl Matter

Dividing epithelial cells need to coordinate spindle positioning with shape changes to maintain cell-cell adhesion. Microtubule interactions with the cell cortex regulate mitotic spindle positioning within the plane of division. How the spindle crosstalks with the actin cytoskeleton to ensure faithful mitosis and spindle positioning is unclear. Here we demonstrate that the tumour suppressor DLC...

ژورنال: :مجله دانشگاه علوم پزشکی کردستان 0
عبدالرضا کاظمی abdolreza kazemi faculty of literature & humanities, vali-e-asr university of rafsanjan, rafsanjan, iranدانشکده ادبیات و علوم انسانی، دانشگاه ولی عصر (عج) رفسنجان،رفسنجان، ایران مسعود رحمتی masood rahmati faculty of literature & humanities, lorestan university, khoramabad, iran.دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، خرم آباد، ایران علی نژاد زمانی ali nezhadzamani student in master of xexrcise physiology, eslamic azazd university of kerman.دانشجوی کارشناسی ارشد فیزیولوژی ورزشی، دانشگاه آزاد اسلامی واحد کرمان.

مقدمه: اختلال در پروتئین های حرکتی درگیر انتقال آکسونی یکی از علائم رایج در بیماری های تخریب عصبی است. kif1b یکی از این پروتئین های حرکتی درگیر در انتقال آکسونی است. هرچند گزارشات بسیاری در مورد اختلال این پروتئین و بیان آن در بیماری های مختلف سیستم عصبی مرکزی وجود دارد، با این حال مشخص نیست آیا در حالت فعالیت کاهش یافته به شکل لیگاتور بندی نخاع میزان بیان kif1b را در اعصاب محیطی تغییر می دهد ی...

2012
Ahmed Al-Qahtani Mashael Al-Anazi Nisha A. Viswan Nisreen Khalaf Ayman A. Abdo Faisal M. Sanai Hamad Al-Ashgar Mohammed Al-Ahdal

BACKGROUND/AIM Kinesin family member 1B (KIF1B) gene resides in the chromosomal region 1p36.22 and has been reported to have frequent deletions in a variety of human cancers. A recent genome wide association study (GWAS) study conducted on a Chinese population has reported the involvement of a KIF1B genetic variant in Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). This study ai...

2013
Zhi-Chao Wang Qiang Gao Jie-Yi Shi Liu-Xiao Yang Jian Zhou Xiao-Ying Wang Ying-Hong Shi Ai-Wu Ke Guo-Ming Shi Zhen-Bin Ding Zhi Dai Shuang-Jian Qiu Jia Fan

BACKGROUND Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors. Recently, a genome-wide association study revealed an association between polymorphisms in the KIF1B gene and the risk of hepatocellular carcinoma (HCC), and several case-control studies have further investigated this relationship. However, these studies have yielded controversial resu...

2017
Mingkuan Su Jianfeng Guo Jiancheng Huang

BACKGROUND/AIMS The association between the kinesin family member 1B (KIF1B) gene polymorphism and the risk of hepatitis B virus-related hepatocellular carcinoma (HCC) has been investigated in many peer-reviewed studies. However, scholars have failed to replicate these results in validation tests. The purpose of the present study was to explore whether the KIF1B rs17401966 polymorphism was asso...

2014
Jessica R. Maximino Gabriela P. de Oliveira Chrystian J. Alves Gerson Chadi

Early molecular events related to cytoskeleton are poorly described in Amyotrophic Lateral Sclerosis (ALS), especially in the Schwann cell (SC), which offers strong trophic support to motor neurons. Database for Annotation, Visualization and Integrated Discovery (DAVID) tool identified cytoskeleton-related genes by employing the Cellular Component Ontology (CCO) in a large gene profiling of lum...

2012
Rong Zhong Yao Tian Li Liu Qian Qiu Ying Wang Rui Rui Bei-Fang Yang Sheng-Yu Duan Jun-Xin Shi Xiao-Ping Miao Li Wang Hui Li

BACKGROUND A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepa...

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