objective to determine the role of ketogenic diet in the treatment of intractable epilepsy in children. materials & methods sixty six consecutive children (1-16 years old) with intractable epilepsy whose seizure were not neurodegenerative nor febrile in origin were recruited. they received the ketogenic diet and we evaluated its effect on seizure frequency for 3 months. all these children had m...

objective the aim of the present study was to evaluate the efficacy and tolerability of a modified atkins diet for intractable childhood epilepsy. materials & methods twenty one children with medically intractable epilepsy were enrolled in the study. inclusion criteria were at least four seizures per month and a trial of at least three anticonvulsants without becoming seizure-free. the subjects...

BACKGROUND AND PURPOSE Despite the successful use of a ketogenic diet in pediatric epilepsy, its application in adults has been limited. The aim of this meta-analysis was to summarize the findings of relevant published studies in order to identify the efficacy of and compliance with a ketogenic diet and its main subtypes (i.e., classic ketogenic diet and modified Atkins diet) in adults with int...

how to cite this article: ghazavi a, tonekaboni sh, karimzadeh p, nikibakhsh aa, khajeh a, fayyazi a. the ketogenic and atkins diets effect on intractable epilepsy: a comparison. iran j child neurol. 2014 summer;8(3): 12-17. abstract objective intractable epilepsy is a major difficulty in child neurology, because the numbers of drugs that are available for treatment are limited and new treatmen...

Objective: This study aimed to determine the efficacy of a medium-chain triglyceride ketogenic diet on patients with drug-resistant epilepsy over a period of 1 year and 8 months. Methods: Patients with refractory epilepsy on a medium-chain triglyceride ketogenic diet were prospectively enrolled. Their clinical condition and the effectiveness of the ketogenic diet were followed-up every month fo...

objective the ketogenic diet is a high-fat, low carbohydrate, adequate protein diet,developed in the 1920s for the management of intractable seizure disorders in children. to evaluate efficacy and tolerability of the classic  ketogenic diet, we analyzed records of the children started on the diet from 1999 to 2006 at the mofid children's hospital.materials & methods   the subjects were 87 child...

ATP and adenosine are purines that play dual roles in cell metabolism and neuronal signaling. Acting at the A(1) receptor (A(1)R) subtype, adenosine acts directly on neurons to inhibit excitability and is a powerful endogenous neuroprotective and anticonvulsant molecule. Previous research showed an increase in ATP and other cell energy parameters when an animal is administered a ketogenic diet,...

Ketogenic diets are very low in carbohydrates and can reduce epileptic seizures significantly. This dietary therapy is particularly effective in pediatric and drug-resistant epilepsy. Hypothesized anticonvulsant mechanisms of ketogenic diets focus on increased inhibition and/or decreased excitability/excitation. Either of these consequences might not only reduce seizures, but also could affect ...

PURPOSE The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, we analyzed the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model. MATERIALS AND METHODS KA-administered rats were fed the ketogenic diet or a normal diet for 4 weeks, and microarray analysis was...