Sequential Wolff rearrangement of α-diazo-β-ketoesters followed by trapping of the ketene intermediates with enol ethers generated a variety of γ,δ-unsaturated β-ketoesters. This method involves a novel thermal cascade reaction and allows the synthesis of γ,δ-unsaturated β-ketoesters with trans-stereochemistry under catalyst-free conditions. The synthesized compounds were further transformed in...

This study presents the bioreduction of six β-ketoesters by whole cells of Kluyveromyces marxianus and molecular investigation of a series of 13 β-ketoesters by hologram quantitative structure-activity relationship (HQSAR) in order to relate with conversion and enantiomeric excess of β-stereogenic-hydroxyesters obtained by the same methodology. Four of these were obtained as (R)-configuration a...

This paper describes step-economic iodine-mediated construction of functionalized arylazopyrazoles in the presence of catalytic AgNO3 starting from simple β-ketoesters and two equivalents of arylhydrazines. This cascade reaction includes in situα-iodination of β-ketoesters, pyrazol-3-one formation, substitution with a nitrogen nucleophile, and oxidation/aromatization.

Transesterification, one of the most effective methods for ester synthesis, is usually conducted under acid or basicconditions. Although quite a few methods have been reported for transesterification, they are not general as far asp-ketoesters are concerned. Some of these methods used toxic, expensive reagents and in relatives large amount. Inthis research, transesterification reaction six type...

Abstract Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols α-methoxy-β-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans in the presence water. In synthetic process benzofurans, α-methoxy-β-ketoesters converted into α-methoxyacetophenones, methoxy group is an important element annul...

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.

transesterification, one of the most effective methods for ester synthesis, is usually conducted under acid or basicconditions. although quite a few methods have been reported for transesterification, they are not general as far asp-ketoesters are concerned. some of these methods used toxic, expensive reagents and in relatives large amount. inthis research, transesterification reaction six type...

The first example of catalytic asymmetric 1,2-addition of arylboronic acids to heteroaryl α-ketoesters has been developed for the highly efficient and enantioselective synthesis of quaternary carbon-containing heteroaromatic α-hydroxy esters. The reaction works well with a variety of α-ketoesters including 3-indoleglyoxylates, 3-benzofuranglyoxylates and 3-benzothiopheneglyoxylates under very m...

Reactions of 2-amino-aryl alcohols with beta-ketoesters catalyzed by a catalytic amount of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation-cyclization, 2-nitrophenyl propargyl alcohols with beta-ketoesters catalyzed by FeCl3 and SnCl2 also produce the 4-alkyne-3-quinolinecarboxyl...

Efficient synthesis of fluorinated organic compounds, which plays an important role in the research of biological and medicinal chemistry, and material science, is now becoming one of the most dynamic aspects of modern organic chemistry. Among several strategies for this purpose, late-stage fluoromethylation using easy-to-handle reagents under mild conditions is principally advantageous for the...