PURPOSE To develop a device that facilitates the procurement of corneal limbal stem cell grafts for keratolimbal allograft procedures used in the treatment of ocular surface disease associated with stem cell deficiency. DESIGN Description of device design and technique for use. METHODS The device is composed of a pedestal with a convex surface mounted to a flat platform. A corneoscleral but...

BACKGROUND To perform lamellar keratolimbal allograft transplantation in a one-step procedure with a single graft, we investigated the feasibility of harvesting eccentric lamellar keratolimbal grafts from conventionally processed corneoscleral buttons using a manually guided microkeratome in conjunction with an artificial anterior chamber system. METHODS We used the Moria LSK-One microkeratom...

purpose: to investigate the outcomes of keratolimbal allograft (klal) for treatment of total limbal stem cell deficiency (lscd). method: patients with total lscd and adequate tear production were included. a total of 27 klal procedures were performed in 21 eyes of 20 patients with lscd. immunosuppression was achived using mycophenolate and cyclosporine. main outcome measure was improvement in v...

PURPOSE To investigate the long-term outcome of keratolimbal allograft (KLAL) for the treatment of severe ocular surface disorders. DESIGN Retrospective, noncomparative case series. PARTICIPANTS Twenty patients (23 eyes) with severe ocular surface disorders. INTERVENTION Thirty-three KLAL procedures were performed. Ten patients (10 eyes) underwent KLAL in combination with other surgical p...

The purpose of our review was to familiarize the readers with the new concepts in ocular surface diseases and reconstruction. Limbal stem cell deficiency is characterized by the progressive invasion of conjunctival epithelial cells onto the cornea, superficial vascularisation, destruction of the corneal basement membrane, and chronic inflammatory cell infiltration. Depending on the severity of ...

PURPOSE To report a case of unilateral total limbal stem cell (LSC) failure and corneal opacification secondary to thimerosal- and contact lens-induced ocular surface toxicity. METHODS Interventional case report and review of the literature on thimerosal-induced ocular surface changes. RESULTS A 49-year-old woman with a 2-year history of long-term soft contact lens wear developed unilateral...

Purpose. Keratolimbal allograft (KLAL) is a treatment for limbal stem cell deficiency. One disadvantage is systemic immunosuppression to avoid rejection. Our purpose was to examine the adverse effects of systemic immunosuppression in KLAL. Methods. A retrospective case review of 16 patients with KLAL who received systemic immunosuppression consisting of a corticosteroid, an antimetabolite, and/...