Genital human papillomaviruses (HPV) represent the most common sexually transmitted agents and are classified into low or high risk by their propensity to cause genital warts or cervical cancer, respectively. Topical microbicides against HPV may be a useful adjunct to the newly licensed HPV vaccine. A main objective in the development of novel microbicides is to block HPV entry into epithelial ...

Respiratory syncytial virus (RSV) exploits cell surface heparan sulfate proteoglycans (HSPGs) as attachment receptors. The interaction between RSV and HSPGs thus presents an attractive target for the development of novel inhibitors of RSV infection. In this study, selective chemical modification of the Escherichia coli K5 capsular polysaccharide was used to generate a collection of sulfated K5 ...

PURPOSE The purpose of this study was to evaluate the inhibitory effects of the nanoparticle-mediated delivery of plasminogen kringle 5 (K5) on choroidal neovascularization (CNV) and retinal inflammation. METHODS CNV was induced by laser in adult rats. Nanoparticles with an expression plasmid of K5 (K5-NP) were injected into the vitreous. K5 expression was detected by immunohistochemistry. Th...

Walton and Welsh proved that if a co-loopless regular matroid M does not have minor in {M(K(3,3)),M∗(K5)}, then admits nowhere zero 4-flow. Lai, Li Poon {M(K5),M∗(K5)}, We prove {M((P10)¯3 ),M∗(K5)}, 4-flow where (P10)¯3 is the graph obtained from Petersen P10by contracting 3 edges of perfect matching. As both M(K3,3) M(K5) are contractions M((P10)¯3), our result extends results Poon.

The prostate epithelium is composed of basal (BC), luminal (LEC), and neuroendocrine (NEC) cells. It is unclear how many subtypes of BCs in the prostate and which subtype of BCs contains the main stem cell niche in the adult prostate. Here we report seven BC subpopulations according to their p63, cytokeratin 14 (K14) and K5 expression patterns, including p63-positive/K14-negative/K5-negative (p...

The intracellular expression of the K5 lyase enzyme, which degrades the K5 polysaccharide, decreased cell surface expression of the Escherichia coli K5 capsule. This indicates that biosynthesis of K5 polysaccharide in the cytoplasm is accessible to the action of K5 lyase and is not synthesized within a protected cytoplasmic compartment.

R(C4, K4) = 10 (see [2]) R(C4, K5) = 14 (see [3]) R(C5, K4) = 13, R(C5, K5) = 17 (see [5, 6]) R(Cn, K3) = 2n − 1 (n > 3) (see [4, 7]). In [10], we proved that R(Cn, K4) = 3(n − 1) + 1 (n ≥ 4). In this paper, we will prove that R(Cn, K5) = 4(n − 1)+ 1 (n = 6, 7). The following notations will be used in this paper. If G is a graph, the vertex set (resp. edge set) of G is denoted by V (G) (resp. E...

OBJECTIVE The aim of the study is to evaluate the effect of nanoparticle-mediated gene delivery of angiogenic inhibitors on retinal inflammation, vascular leakage, and neovascularization in diabetic retinopathy. RESEARCH DESIGN AND METHODS An expression plasmid of plasminogen kringle 5 (K5), a natural angiogenic inhibitor, was encapsulated with poly(lactide-coglycolide) to form K5 nanoparticl...

Let Km −H be the graph obtained from Km by removing the edges set E(H) of H where H is a subgraph of Km. In this paper, we characterize the potentially K5 − P3, K5 − A3, K5 −K3 and K5 − K1,3-graphic sequences where A3 is P2 ∪ K2. Moreover, we also characterize the potentially K5 − 2K2-graphic sequences where pK2 is the matching consisted of p edges.