introduction: our previous studies showed that hydroalcoholic extract of leaf of vitis vinifera relaxes the phenylephrine-induced contraction in rat thoracic aorta. this effect was dependent on endothelial integrity and no-cgmp system. the vasorelaxant effect of extract was much lesser on kcl-induced contraction. we, therefore, postulated that k+ channels are involved. the main aim of the prese...

Introduction: Hydrogen sulfide (H2S) plays a key role in the regulation of vascular tone and protection of blood vessels against endothelial dysfunction. Since the mechanism of salt impairing H2S-induced vascular relaxation is not fully clear, therefore this study was designed to investigate the role of potassium (K+) channels in the vasodilatory effects of exogenous H2S in rat aortic rings.&nb...

introduction: hydrogen sulfide (h2s) plays a key role in the regulation of vascular tone and protection of blood vessels against endothelial dysfunction. since the mechanism of salt impairing h2s-induced vascular relaxation is not fully clear, therefore this study was designed to investigate the role of potassium (k+) channels in the vasodilatory effects of exogenous h2s in rat aortic rings. ma...

Introduction Numerous studies have demonstrated the presence of potassium selective channels in membranes internal organelles. These channels are essential to a large variety of cellular processes including intracellular 2+ a signaling, protein recycling, charge neutralization and cell protection. In contrast to the sarcoplasmic reticulum + here potassium channels have been clearly ...

embryonic stem cells are capable of differentiating to variety of cell tissues including cardiomyocytes. this developmental change is accompanied with a great deal of ion channel expression and functions. mouse stem cell derived cardiomyocytes were prepared and separated to yield isolated single cell suspension for cell current recording. in the present study some properties of the k + -current...