Provisional hypomyopathic juvenile dermatomyositis is a subgroup of clinically amyopathic juvenile dermatomyositis provisional. The diagnostic criteria include: Classic dermatomyositis skin lesions – which have to be confirmed by biopsy –, no involvement of proximal muscles, subclinical involvement of these muscles and normal level of muscle enzymes. These criteria should be present for a minim...

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INTRODUCTION Infections can act as a trigger for juvenile dermatomyositis, with a predominance of respiratory tract infections reported previously. We present the first case of juvenile dermatomyositis following varicella infection to be described in the literature. CASE PRESENTATION A 15-month-old Caucasian girl was diagnosed with juvenile dermatomyositis 3 months after a varicella infection...

A link between dermatomyositis and neoplasia has long been suspected. The precise incidence of this association remains controversial, owing to varying criteria used to diagnose dermatomyositis. Although juvenile dermatomyositis is believed to display no association with neoplasm, there have been few reported cases of dermatomyositis associated with tumors of any kind in pediatric age group (1-...

OBJECTIVE To analyze major histocompatibility complex expression in the muscle fibers of juvenile and adult dermatomyositis. METHOD In total, 28 untreated adult dermatomyositis patients, 28 juvenile dermatomyositis patients (Bohan and Peter's criteria) and a control group consisting of four dystrophic and five Pompe's disease patients were analyzed. Routine histological and immunohistochemica...

References 1. McCann LJ, Juggins AD, Maillard SM, Wedderburn LR, Davidson JE, Murray KJ, Pilkington CA: Juvenile Dermatomyositis Research Group. The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland)–clinical characteristics of children recruited within the first 5 yr. Rheumatology 2006, 45(10):1255-1260. 2. Laskin BL, Choyke P, Keenan GF, Miller FW, Rider LG: Novel gast...

INTRODUCTION The idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by chronic muscle inflammation resulting progressive weakness and frequent involvement of internal organs, mainly the pulmonary, gastrointestinal and cardiac systems. OBJECTIVE To present clinical characteristics, disease course, frequency of relapses and survival of 79 patients with juvenile or...

Introduction Dermatomyositis is associated with an increased risk of malignancy, however, universal screening guidelines are not established. Recently the p155 antibody has been reported, along with an association with malignancy in dermatomyositis. The aim of this paper is to review the literature on the p155 antibody in DM and explore the implications this new marker may have in the clinical ...

Introduction Juvenile Dermatomyositis (JDM) is a systemic autoimmune disorder in which the immune system targets the microvasculature of skeletal muscles, skin and other organs, with for the most part an unknown immunopathogenesis. Moreover, evaluation of disease activity remains challenging in juvenile dermatomyositis as muscle enzyme levels and inflammatory markers, routinely used in clinics,...