The passing of human tumour tissue through a series of immunodeficient nude mice (“serial passaging”) has been an important model system in cancer research for more than 40 years (Rygaard & Povlsen, 1969). Such xenograft models have the advantage of unlimited availability of live tumour tissue, allowing for repeated experiments on the same tumour. It has been shown by various techniques, includ...

This paper proposes a weight initialization strategy for a discrete-time recurrent neural network model. It is based on analyzing the recurrent network as a nonlinear system, and choosing its initial weights to put this system in the boundaries between different dynamics, i.e., its bifurcations. The relationship between the change in dynamics and training error evolution is studied. Two simple ...

Materials and Methods: 1391 individuals (age 45-64 years old) randomly selected from Dental Atherosclerosis Risk in Communities Study (Dental ARIC). Clinical measures collected included PD, CAL on six sites for all teeth. Case definition of periodontal disease consists of following three degrees; 1) severe periodontitis: >2 interproximal sites ( not on same tooth) with > 6mm CAL and 1 or more i...

In female rats, food intake is reduced during the period in the estrous cycle when the rat is sexually receptive and ovulation is imminent (Wade and Gray, 1979). By contrast, food intake is increased during lactation in the postpartum period (Linden et al, 1990) and sexual behaviour and ovulation are inhibited (Sodersten et al, 1983). There are several examples demonstrating that the neuroendoc...

Spinocerebellar ataxia (SCA) 3, the most common form of SCA, is a neurodegenerative rare disease characterized by polyglutamine tract expansion and self-assembly of Ataxin3 (At3) misfolded proteins into highly organized fibrillar aggregates. The At3 N-terminal Josephin Domain (JD) has been suggested as being responsible for mediating the initial phase of the At3 double-step fibrillogenesis. Sev...