نتایج جستجو برای: jak2v617f mutation

تعداد نتایج: 291772  

A Ghasemi, A Ghotaslou, B Chahardouli, F Nadali, S Abbasian, S Rostami,

Background Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene were described in patients with Philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of present study was to investigate the fre...

Journal: :iranian journal of pediatric hematology and oncology 0
a ghotaslou ms.c student , department of hematology,school of allied medical sciences , tehran university of medical sciences, tehra f nadali associate professor, departement of hematology, school of allied medical sciences , tehran university of medical scienceسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) a ghasemi سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) b chahardouli - assistant professor, hematology-oncology and stem cell transplantation research center, tehran university of medical s s abbasian سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) s rostami - assistant professor, hematology-oncology and stem cell transplantation research center, tehran university of medical s

background myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. in addition to jak2v617f mutation, several mutations in the c-mpl gene were described in patients with philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. the aim of present study was to investigate the frequ...

Journal: :international journal of hematology-oncology and stem cell research 0
mehrdad payande medical biology research center, kermanshah university of medical sciences, kermanshah, iran mohammad erfan zare medical biology research center, kermanshah university of medical sciences, kermanshah, iran; student saber ghanbari haji shure student of medical lab sciences in research committee, kermanshah university of medical sciences, kermanshah, iran farhad shaveisi zadeh medical genetics department, faculty of medicine, shahid beheshti university of medical sciences and

myeloproliferative neoplasms (mpns) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. philadelphia chromosome is a sure way to definitively diagnose cml. recently, jak2v617f mutation introduced as a diagnostic marker for other myeloprol...

Journal: :international journal of hematology-oncology and stem cell research 0
akram asghari hematology-oncology department, rasul akram hospital, tehran university of medical sciences, tehran, ali shahriari ahmadi hematology-oncology department, rasul akram hospital, tehran university of medical sciences, tehran, iran ali basi hematology-oncology department, firoozgar hospital, tehran university of medical sciences, tehran, iran masood vkili hematology-oncology department, rasul akram hospital, tehran university of medical sciences, tehran, iran mohsen razavi hematology-oncology department, firoozgar hospital, tehran university of medical sciences, tehran, iran mohsen arabi hematology-oncology department, rasul akram hospital, tehran university of medical sciences, tehran, iran

introduction : myeloproliferative neoplasms (mpns) are a group of clonal malignant hematologic disease, where the main and common members are; polycythemia vera (pv), primary myelofibrosis (pmf), and essential thrombocytosis (et). these group of diseases are able to be transformed into each other. methods:   this cross sectional study conducted the evaluation of jak2v161f mutation in dna in per...

2016
Shixiang Zhao Xiang Zhang Yang Xu Yufeng Feng Wenhong Sheng Jiannong Cen Depei Wu Yue Han

Most patients with polycythemia vera (PV) and half of essential thrombocythemia (ET) possess an activating JAK2V617F mutation. The objective of this study was to better define the effect of JAK2V617F mutant allele burden on clinical phenotypes in Chinese patients, especially thrombosis. By real-time polymerase chain reaction (RT-PCR), the JAK2V617F mutation burden was detected in 170 JAK2V617F-...

2016
İpek Yönal Aynur Dağlar-Aday Başak Akadam-Teker Ceylan Yılmaz Meliha Nalçacı Akif Selim Yavuz Fatma Deniz Sargın

OBJECTIVE The JAK2V617F mutation is present in the majority of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). The impact of this mutation on disease phenotype in ET and PMF is still a matter of discussion. This study aims to determine whether there are differences in clinical presentation and disease outcome between ET and PMF patients with and without the JAK2V61...

2012
Dongqing Yan Robert E. Hutchison Golam Mohi

The JAK2V617F mutation has been detected in most cases of Ph-negative myeloproliferative neoplasms (MPNs). The JAK2V617F protein is a constitutively activated tyrosine kinase that leads to transformation of hematopoietic progenitors. Previous studies have shown that several tyrosine residues within JAK2 are phosphorylated on growth factor or cytokine stimulation. However, the role of these tyro...

Journal: :Genetics and molecular research : GMR 2013
H-H Hsiao Y-C Liu M-Y Yang Y-F Tsai T-C Liu C-S Chang S-F Lin

Gain of function mutation of Janus kinase 2 (JAK2V617F) has been identified in Philadelphia-negative myeloproliferative diseases; about half of essential thrombocythemia (ET) patients harbor this mutation. The activated JAK-STAT pathway promotes cell proliferation, differentiation and anti-apoptosis. We studied the role of negative regulators of the JAK-STAT pathway, PIAS, and SOCS in ET patien...

Journal: :international journal of hematology-oncology and stem cell research 0
parisa karimzadeh school of allied health sciences, tehran university of medical sciences seyed hamidollah ghaffari hematology-oncology and stem cell research center, shariati hospital, tehran university of medical sciences shirin ferdowsi school of allied health sciences, tehran university of medical sciences bahram chahardouli hematology-oncology and stem cell research center, shariati hospital, tehran university of medical sciences zohreh saltanatpouri hematology-oncology research center, emam khomeini hospital, tehran university of medical sciences nahid einollahi school of allied health sciences, tehran university of medical sciences

background and objectives: jak2 is a nonreceptor tyrosine kinase that plays a major role in myeloid disorders. jak2v617f mutation is characterized by a g to t transverse at nucleotide 1849 in exon 12 of the jak2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the jak2 protein. in this study we compared two molecular methods ...

2013
Benoit de Renzis Veronique Mansat-De Mas Eric Wattel Odile Beyne-Rauzy Laurent Knoops Aurélie Cabrespine Zahia Azgui Lionel Ades Jean-Jacques Kiladjian Pierre Fenaux

While in RARS-T, JAK2V617F mutation is common and associated with good prognosis, the clinical and prognostic impact of this mutation in other MDS is unknown. We collected data from 132 non-RARS-T MDS with known JAK2V617F mutation status. JAK2V617F mutation was significantly correlated with lower progression to AML (p<.0011) and better overall survival (OS, p=.011). OS difference persisted afte...

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