In a selected group of human immunodeficiency virus (HIV)-infected patients we confinn the expansion of a COS+ T-Iymphocyte subset, Le. , the CD8+/Leu7+ cells, which account for 300/0 ofthe Iymphocytes, compared to 3% in the control donors. In addition, a e08+ T-Iymphocyte suhset that coexpresses dass 11 (DR) antigens, Le., COS·,., DR+ cells, is also increased from 1.5% in controls to 27% in th...

Immunofluorescence studies and mixed Iymphocyte islet culture (MLlC) tests were performed using cryopreserved crude human islet preparations l and various HLAas well as cell type-specific monoclonal antibodies in order to (a) locate the potentially immunogenic cells and (b) demonstrate their functional relevance before and after antibody incubation. Microscopic evaluation of exocrine and endocr...

Ten diffuse histiocytic lymphoma (DHL) cell lines were extensively characterized with monoclonal antibodies and histochemical techniques. The original biopsy specimens. representing nine of ten cases from which the cell lines were derived. were reviewed utilizing the International Working Formulation. Eight of ten cell lines reacted with antiimmunoglobulin reagents and/or a subset of B-Iymphocy...

A 5 year-old boy presented with recurrent arthritis associated with fever first at 2 years and later at 3 and 5 years of age. He had an affected (hypogammaglobulinemic) elder sister with severe recurrent infections. His younger male sibling is normal. The parents are consanguineous but unaffected. His immunologic parameters indicated panhypogammaglobulinemia, normal absolute Iymphocyte counts b...

NATURAL xenophile antibodies (NXA) and induced xenophile antibodies (XA) are considered a major barrier to organ transplantation between phylogeneticaliy discordant species and are held to be responsible for hyperacute and acute rejection of xenogeneic organs.! The aims of this study were (1) to analyze the kinetics of NXA and XA in the xenogeneic model "rat antihuman," which allows experimenta...

Human umbilical vein endothelial cells were cultured in supernatants of peripheral blood monocytes that had been cultured for 3 days with and without lactoferrin. Colonystimulating activity (CSA) was measured in supernatants of the endothelial cell cultures and appropriate control cultures using normal. T-Iymphocyte-depleted. phagocytedepleted, low-density bone marrow cells in colony growth (CF...

Beta-endorphin (fS-EP) is a 31 amino acid polypeptide secreted by the pituitary, brain, and various other tissues. it has potent opiate-like activity, can produce analgesia, and may play a physiological role in adapting the immune system to stress by affecting Iymphocyte and complement binding activity. To investigate the effect of fS-EPon pain threshold, we analyzed cerebrospinal fluid (CSF) a...

The immunosuppressive effects of cisplatin at relatively low doses were investigated in CD-1 mice, Mice were injected intraperitonea]ly with 8, 40 and 20e yglkg cisplatin for 10 days, A decrease in bedy and thymus weights was observed at 200Ag!kg, Though there were no dose-related effects on the IgM antibody response to sheep erythrocytes, a statistically significant reduction of the contact hy...

OBJECTIVE To evaluate the contribution of cytotoxic T-Iymphocyte antigen-4(CTLA-4)+49A/G polymorphism to the susceptibility to type-1 diabetes (T1D) in Turkish children. METHODS A case-control study was designed to include 91 Turkish children with T1D and 99 healthy controls. CTLA-4 (+99A/G) gene polymorphism typing was done by PCR amplification followed by restriction fragment length polymor...

human brucellosis is a major health problem in developing countries. a number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. since the pathophysiology of this change is not well understood, we studied the t-cell subsets during the acute, subacute and chronic forms of human brucellosis. in this study we found alterations in t...