نتایج جستجو برای: itpa

تعداد نتایج: 206  

Journal: :Journal of molecular biology 2009
Elena I Stepchenkova Elena R Tarakhovskaya Kathryn Spitler Christin Frahm Miriam R Menezes Peter D Simone Carol Kolar Luis A Marky Gloria E O Borgstahl Youri I Pavlov

Sanitization of the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic, and toxic incorporation of purine base analogues [i.e., ITP, dITP, XTP, dXTP, or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into ...

2005
M. Behmanesh K. Sakumi D. Tsuchimoto K. Torisu Y. Ohnishi-Honda D. E. Rancourt Y. Nakabeppu

In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns, located on chromosome 2F3, which was isolated by a retro-recombination method. We also identified three types (A, B, C) of Itpa transcripts in mouse tissues. The processed Itpa gene-like sequence located on chromosome 2E1 has a complete open readin...

2010
Nona Abolhassani Teruaki Iyama Daisuke Tsuchimoto Kunihiko Sakumi Mizuki Ohno Mehrdad Behmanesh Yusaku Nakabeppu

Mammalian inosine triphosphatase encoded by ITPA gene hydrolyzes ITP and dITP to monophosphates, avoiding their deleterious effects. Itpa(-) mice exhibited perinatal lethality, and significantly higher levels of inosine in cellular RNA and deoxyinosine in nuclear DNA were detected in Itpa(-) embryos than in wild-type embryos. Therefore, we examined the effects of ITPA deficiency on mouse embryo...

2016
Yasuto Yoneshima Nona Abolhassani Teruaki Iyama Kunihiko Sakumi Naoko Shiomi Masahiko Mori Tadahiro Shiomi Tetsuo Noda Daisuke Tsuchimoto Yusaku Nakabeppu

Deoxyinosine (dI) occurs in DNA either by oxidative deamination of a previously incorporated deoxyadenosine residue or by misincorporation of deoxyinosine triphosphate (dITP) from the nucleotide pool during replication. To exclude dITP from the pool, mammals possess specific hydrolysing enzymes, such as inosine triphosphatase (ITPA). Previous studies have shown that deficiency in ITPA results i...

Journal: :Molecular medicine reports 2012
Takashi Nishimura Rie Osaki Makoto Shioya Hirotsugu Imaeda Tomoki Aomatsu Takayuki Takeuchi Yoshiaki Okumura Yoshihide Fujiyama Akira Andoh

Ribavirin (RBV)-induced anemia is a serious side effect of pegylated interferon (PEG-IFN) plus RBV therapy which is the standard care most effective for hepatitis C virus (HCV) infection. In the present study, we investigated the association of inosine triphosphate pyrophosphatase (ITPA) genotypes with RBV-induced hemoglobin (Hb) reduction in HCV patients treated with PEG-IFN/RBV therapy. The g...

Journal: :Mutation research 2010
Kunihiko Sakumi Nona Abolhassani Mehrdad Behmanesh Teruaki Iyama Daisuke Tsuchimoto Yusaku Nakabeppu

Inosine triphosphate pyrophosphatase (ITPA protein) (EC 3.6.1.19) hydrolyzes deaminated purine nucleoside triphosphates, such as ITP and dITP, to their corresponding purine nucleoside monophosphate and pyrophosphate. In mammals, this enzyme is encoded by the Itpa gene. Using the Itpa gene-disrupted mouse as a model, we have elucidated the biological significance of the ITPA protein and its subs...

Journal: :CPT: pharmacometrics & systems pharmacology 2016
L S Wu L C Jimmerson C E MacBrayne J J Kiser D Z D'Argenio

Ribavirin remains an important component of hepatitis C treatment in certain clinical scenarios, but it causes hemolytic anemia. A quantitative understanding of the ribavirin exposure-anemia relationship is important in dose individualization/optimization. We developed a model relating ribavirin triphosphate (RTP) exposure in red blood cells (RBCs), RBC lifespan, feedback regulation of RBC prod...

2014
Alessio Aghemo Eleonora Grassi Maria Grazia Rumi Roberta D'Ambrosio Enrico Galmozzi Elisabetta Degasperi Davide Castaldi Roberta Soffredini Massimo Colombo

BACKGROUND Severe anemia is a common side effect of Pegylated Interferon + Ribavirin (PR) and Telaprevir (TVR) in hepatitis C virus (HCV) genotype 1 patients with advanced fibrosis or cirrhosis (F3-F4). Inosine triphosphatase (ITPA) genetic variants are associated with RBV- induced anemia and dose reduction. AIM To test the association of ITPA polymorphisms rs1127354 and rs7270101 with hemogl...

2016
Katja Lehmann Matthias Söllner Jan Marco Leimeister

In this study, we propose an IT-based peer assessment (ITPA) for enhancing interaction and feedback in universities’ large-scale lectures. These lectures often lack interaction and feedback, and focus on mainly imparting factual knowledge. Hence, these formats often cannot go beyond the basic cognitive levels of educational objectives. Using the ITPA within the learning process helps integratin...

2012
Miriam Rose Menezes Irina S.-R. Waisertreiger Hernando Lopez-Bertoni Xu Luo Youri I. Pavlov

Pure nucleotide precursor pools are a prerequisite for high-fidelity DNA replication and the suppression of mutagenesis and carcinogenesis. ITPases are nucleoside triphosphate pyrophosphatases that clean the precursor pools of the non-canonical triphosphates of inosine and xanthine. The precise role of the human ITPase, encoded by the ITPA gene, is not clearly defined. ITPA is clinically import...

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