نتایج جستجو برای: itih4 protein

تعداد نتایج: 1234701  

2014
Kevin Brown Chandler Zuzana Brnakova Miloslav Sanda Shuo Wang Stephanie H. Stalnaker Robert Bridger Peng Zhao Lance Wells Nathan J. Edwards Radoslav Goldman

Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is a 120 kDa acute-phase glycoprotein produced primarily in the liver, secreted into the blood, and identified in serum. ITIH4 is involved in liver development and stabilization of the extracellular matrix (ECM), and its expression is altered in liver disease. In this study, we aimed to characterize glycosylation of recombinant and serum-deri...

2005
Jin Song Manisha Patel C. Nicole Rosenzweig Yee Chan-Li Lori J. Sokoll Eric T. Fung Nam-Ho Choi-Miura Michael Goggins Daniel W. Chan Zhen Zhang

Background: Several proteolytically derived fragments from the proline-rich region (PRR) of human intertrypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential disease markers. Methods: Previously, we developed a SELDI-based immunoassay that can sim...

2015
Kang-Yun Lee Po-Hao Feng Shu-Chuan Ho Kai-Jen Chuang Tzu-Tao Chen Chien-Ling Su Wen-Te Liu Hsiao-Chi Chuang

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that is correlated with environmental stress. Particulate matter ≤10 μm (PM10) is considered to be a risk factor for COPD development; however, the effects of PM10 on the protein levels in COPD remain unclear. Fifty subjects with COPD and 15 healthy controls were recruited. Gene ontology analysis of differentially ex...

Journal: :Infection and immunity 2004
M Piñeiro M Andrés M Iturralde S Carmona J Hirvonen S Pyörälä P M H Heegaard K Tjørnehøj F Lampreave A Piñeiro M A Alava

We have isolated from calf serum a protein with an apparent M(r) of 120,000. The protein was detected by using antibodies against major acute-phase protein in pigs with acute inflammation. The amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of ITIH4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family. The response of this protein in th...

Journal: :Clinical chemistry 2006
Jin Song Manisha Patel C Nicole Rosenzweig Yee Chan-Li Lori J Sokoll Eric T Fung Nam-Ho Choi-Miura Michael Goggins Daniel W Chan Zhen Zhang

BACKGROUND Several proteolytically derived fragments from the proline-rich region (PRR) of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential disease markers. METHODS Previously, we developed a SELDI-based immunoassay that ...

2005
Niamh Harraghy Timothy J. Mitchell

A porcine genomic library was screened for clones containing the promoter of the major acute-phase protein in pigs, inter-trypsin heavy chain 4 (ITIH4). Following isolation of the promoter, a functional analysis was performed with Hep3B cells. The promoter was induced by interleukin-6 (IL-6) but not by IL-1 . However, IL-1 was shown to inhibit the IL-6-induced activation of the porcine ITIH4 pr...

Journal: :Clinical and diagnostic laboratory immunology 2005
Niamh Harraghy Timothy J Mitchell

A porcine genomic library was screened for clones containing the promoter of the major acute-phase protein in pigs, inter-alpha-trypsin heavy chain 4 (ITIH4). Following isolation of the promoter, a functional analysis was performed with Hep3B cells. The promoter was induced by interleukin-6 (IL-6) but not by IL-1beta. However, IL-1beta was shown to inhibit the IL-6-induced activation of the por...

2014
Mostafa M. Sira Behairy E. Behairy Azza M. Abd-Elaziz Sameh A. Abd Elnaby Ehab E. Eltahan

Liver fibrosis and viremia are determinant factors for the treatment policy and its outcome in chronic hepatitis C virus (HCV) infection. We aimed to investigate serum level of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and its relation to liver fibrosis and viremia in children with chronic HCV. ITIH4 was measured by ELISA in 33 treatment-naive children with proved chronic HCV and comp...

2013
Hao Xu Qinghua Shang Hao Chen Jianpeng Du Jianyan Wen Geng Li Dazhuo Shi Keji Chen

Objective. This trial aims to look for the protein biomarker of "toxin syndrome" of CHD patients. Methods. We have performed two trials in this paper. The first trial was a randomized controlled trial (RCT) of the plasma proteome in unstable angina (UA) patients by Maldi-Tof Mass. The second trial was a nested case-control study in 1503 stable CHD patients with one-year followup for acute cardi...

Journal: :Life science alliance 2021

Here, we recorded serum proteome profiles of 33 severe COVID-19 patients admitted to respiratory and intensive care units because failure. We received, for most patients, blood samples just after admission at two more later time points. With the aim predict treatment outcome, focused on proteins different in abundance between group survivors non-survivors. observed that a small panel about doze...

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