نتایج جستجو برای: isolation mitochondria

تعداد نتایج: 176965  

Journal: :journal of paramedical sciences 0
bahram pooreydy national institute of genetic engineering and biotechnology (nigeb), tehran mohieddin jafari proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran faezeh tajik proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran mehrdad karimi traditional medicine departments, faculty of tradition medicine, tehran university of medical sciences, tehran mostafa rezaei-tavirani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran alireza ghassempour department of phytochemistry, medicinal plants and drugs research institute, shahid beheshti university, tehran

mitochondria play key roles in many cell functions including energy production, fatty acid metabolism, pyrimidine biosynthesis, calcium homeostasis, and aging. they also regulate crucial signaling cascades such as apoptosis and oxidative stress. the proteome is often used to investigate the functional correlations on protein levels. based upon the human, genome there is estimated 2000 to 2500 a...

Journal: :gastroenterology and hepatology from bed to bench 0
pedram azimzadeh reproductive biotechnology research center, avicenna research institute, acecr, tehran, iran hamid asadzadeh aghdaei basic and molecular epidemiology of gastrointestinal disorders, gastroenterology and liver diseases research institute, shahid beheshti university of medical sciences, tehran, iran peyman tarban basic and molecular epidemiology of gastrointestinal disorders, gastroenterology and liver diseases research institute, shahid beheshti university of medical sciences, tehran, iran mohammad mahdi akhondi reproductive biotechnology research center, avicenna research institute, acecr, tehran, iran abolfazl shirazi reproductive biotechnology research center, avicenna research institute, acecr, tehran, iran hamid reza khorram khorshid genetic research center, university of social welfare and rehabilitation sciences, tehran, iran

aim : the aim of this study was to evaluate and compare three available methods for mitochondrial isolation from a human cell line to predict the best method for each probable application.   background : organelle isolation is gaining importance in experimental laboratory settings. mitochondrial dysfunction may affect tumorgenesis process. there are some evidences that transplantation of health...

Journal: :Molecular medicine reports 2012
Bo Tang Liang Zhao Rui Liang Yi Zhang Liming Wang

The ultrastructure, function, and physical and chemical properties of mitochondria have become important issues in scientific research. Current mitochondrial isolation methods mainly rely on the physical and chemical properties of mitochondria. Our team presents a fast and reliable new isolation method based on magnetic nanoparticles binding with ...

Journal: :Fungal Genetics Reports 1969

Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...

Journal: :Biochemical and Biophysical Research Communications 2012

2014
Koji Yamano Adam I Fogel Chunxin Wang Alexander M van der Bliek Richard J Youle

Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson's disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isolation membrane selectively and accurately engulfs damaged mitochondria remains unclear. In this study, we demonstrate that TBC1D15, a mitochondrial R...

Journal: :BioTechniques 2008
Vera Gross Alexander Lazarev Nathan Lawrence Richard Schumacher

Proteomic profiling of mitochondria has the potential to provide insights into mitochondrial functions associated with aging, various metabolic states, and diseases such as cancer, diabetes, and cardiovascular disease [1]. Rapid and reproducible isolation of intact mitochondria is crucial for efficient enrichment and subsequent proteomic analysis of low-abundance mitochondrial proteins [2]. Her...

Journal: :Circulation research 1968
G E Lindenmayer L A Sordahl A Schwartz

For an adequate evaluation of mitochondria from diseased hearts, basic characteristics of isolation, storage, media, ultrastructure and type of assay were first determined using mitochondria from normal animals. A proteinase procedure yielded mitochondria from small laboratory animals, with low respiratory control and marked permeability changes. The isolation medium yielding the most stable mi...

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