Allergies to iron salts are seldom reported. We studied a patient with iron-defi ciency anemia who had suffered anaphylactic reactions caused by oral iron salts. An allergy study was performed using single-blind, placebo-controlled oral challenge and skin tests with various iron salts as well as excipients in commercial formulations. Oral challenges were positive for 2 of the commercial formula...

Iron Salts By KURT R. REISSMANN AND THOMAS J. COLEMAN I N THE PRECEDING PAPER’ the true absorptive nature of acute intestinal iron poisoning was pointed out. Following oral or rectal admimiistration of toxic doses of dissociable iron salts, it was found that excessive amounts of iron were absorbed through the anatomically intact intestinal mucosa, resulting in extraordinarily high serum iron le...

Ferritin-containing fractions with different degrees of iron loading were prepared. All ferritin fractions stimulated the peroxidation of bovine brain phospholipid liposomes, as measured by the formation of thiobarbituric acid-reactive material. This stimulation was increased in the presence of ascorbate. Iron salts of equivalent concentration to those of the ferritin fractions were more stimul...

This article presents data on the fortification of foods, necessary as an important public health approach for the success in reducing anemia. The use of food vehicles, iron salts and their costs, as well as recent work on iron fortification of foods in Brazil are reviewed. Recent research serves as a cornerstone for countries that attempt to implement permanent, long-lasting iron fortification...

1. The effects of KCN and iron salts on oxygen consumption has been studied in the cell of Paramecium caudatum by manometric methods. 2. KCN solutions of strengths from M/200 to M/10,000 have been shown to produce no decrease in oxygen consumption, but have in most cases produced a very slight increase in the respiration rate. 3. The pH values were found to have little or no effect on these res...

Patients with widespread neuroblastoma (NB) frequently have elevated serum ferritin levels, and recently anti-NB effects of the iron chelator deferoxamine (DFO) have been reported. We have investigated the effect of DFO on human bone marrow NB cells from two untreated children with Evans Stage IV disease. DFO treatment caused dose- and time-dependent cytotoxicity of NB cells, with maximal killi...

I t has been previously reported (1) that brains of mice infected with the Theiler FA strain of mouse encephalomyelitis virus show marked inhibition in the rate of glucose phosphorylation. Since such impairment in the utilization of the most essential substrate of brain metabolism may be related to the neuron destruction in the course of the virus infection, its mechanism was investigated furth...

Intestinal absorption of non-heme food iron may be inhibited by tea, which, on the contrary, does not exert any appreciable effect on heme iron assimilation. Therefore, while an iron-deficiency anemia cannot develop in non-vegetarian subjects as a consequence of tea consumption only, it is possible that tea could inhibit the therapeutic effect of oral iron drugs, which are usually non-hemic fer...

Rats fed a corn grit diet containing large amounts of ferric citrate absorb and deposit excessive amounts of iron in their livers. Undoubtedly various factors are involved in iron absorption, but these studies indicate that the low level of dietary phosphate was primarily responsible. The addition of phosphate salts to this diet has shown that the amount of iron deposited in the liver was inver...