The experimental basis for the postulated role of intrinsic ionophores in mitochondrial ion transport and energy coupling is summarized. Intrinsic ionophores appear to be linked to, or contained within, specific ionophoroproteins localized in the inner membrane, and the isolation of these ionophores requires their release from the ionophoroproteins. At least ten different species of ionophores ...

Coccidiosis and coccidiostats Coccidiosis Drugs used to combat coccidiosis Structure of carboxylic acid ionophores Function of carboxylic acid ionophores Use of carboxylic acid ionophores as coccidiostats Coccidiostat residues and human health Legislative backgrounds to residue testing Analytical methods for ionophore residue detection Screening methods for the detection of ionophores In vitro ...

The transport kinetics of the positively charged triphenylmethane dye, malachite green (MG(+)), across liposome bilayers effects the transport of monovalent inorganic cations when ionophores are present in the membrane. Three different types of ionophores characterized by different transport mechanisms have been studied. The ionophores are gramicidin A (gA) (a channel former), valinomycin (VAL)...

The ionophores A23187 and X-537A were used as probes to investigate the possible role of calcium uptake by bone as a mediator for the stimulation of bone resorption induced by parathyroid hormone (PTH) and other agents in cultured mouse calvaria. The ionophores alone at concentrations from 1 nM to 20 ,uM did not stimulate bone resorption, nor did they potentiate bone resorption stimulated by su...

Title of Dissertation: QUANTIFICATION OF IONOPHORE ANTIMICROBIALS ASSOCIATED WITH POULTRY LITTER AND THEIR DYNAMICS IN THE SOILS OF THE MID-ATLANTIC USA Saptashati Biswas, Doctor of Philosophy, 2014 Dissertation directed by: Associate Professor Joshua M. McGrath Department of Environmental Science and Technology Anticoccidants, biochemically known as ionophores are added to poultry feed for gro...

We investigated the effects of calcium removal and calcium ionophores on the behavior and ultrastructure of cultured chick dorsal root ganglia (DRG) neurons to identify possible mechanisms by which calcium might regulate neurite outgrowth. Both calcium removal and the addition of calcium ionophores A23187 or ionomycin blocked outgrowth in previously elongating neurites, although in the case of ...

The drug target profile proposed by the Medicines for Malaria Venture for a malaria elimination/eradication policy focuses on molecules active on both asexual and sexual stages of Plasmodium, thus with both curative and transmission-blocking activities. The aim of the present work was to investigate whether the class of monovalent ionophores, which includes drugs used in veterinary medicine and...

Two ionophores (monensin and gramicidin) that carry Na+ into 3T3 cells markedly enhance the rate of 86Rb+ uptake. Ouabain prevents both ionophores from increasing 86Rb+ uptake, indicating that the ionophores activate the Na+,K+ pump. Measurements of 86Rb+ uptake and cell Na+ and K+ over a range of monensin concentrations show that the activity of the Na+,K+ pump in 3T3 cells is limited by the s...

Zinc plays an important role in the regulation of many cellular functions; it is a signaling molecule involved transduction several cascades response to intra and extracellular stimuli. Labile zinc small fraction total intracellular zinc, that loosely bound proteins easily interchangeable. At level, molecules can bind labile promote its passage across lipophilic membranes. Such are known as ion...