Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of antioxidant therapies for the management of ionizing irradiation injury fall into three categories: (1) radiation counter measures against total or partial body irradiation; (2) normal tissue protection against acute organ specific ionizing irradiation injury; and (3) prevention of chronic/late radiatio...

Introduction It has long been known that ionizing radiation can lead to detrimental effects in normal cells. In this light, Radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. This study aimed to evaluate the radio-protective effect of N-acetylcysteineagainst radiation-induced mortality in male mice. Materials and Methods 52 healthy mal...

Introduction: The effects of the low dose of ionizing radiation are not thoroughly evident due to an unavoidable increase of occupational exposure and the widespread application of ionizing radiation in medical and industrial fields. The aim of this study was to investigate immune system responses following the low doses of ionizing radiation. Materia...

this study was conducted to evaluate the effect of electron beam irradiation at doses of 250 and 500 kgy on the chemical composition and ruminal dry matter (dm) and neutral detergent fiber (ndf) degradability of wheat straw. nylon bags of untreated or irradiated wheat straw were suspended in the rumen of three rams for up to 72 h, and resulting data were fitted to non-linear degradation model t...

introduction it has long been known that ionizing radiation can lead to detrimental effects in normal cells. in this light, radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. this study aimed to evaluate the radio-protective effect of n-acetylcysteineagainst radiation-induced mortality in male mice. materials and methods 52 healthy male m...

Macroautophagy (mAG) is a lysosomal mechanism of degradation of cell self-constituents damaged due to variety of stress factors, including ionizing irradiation. Activation of mAG requires expression of mAG protein Atg8 (LC3) and conversion of its form I (LC3-I) to form II (LC3-II), mediated by redox-sensitive Atg4 protease. We have demonstrated upregulation of this pathway in the innate host de...

delivery of macromolecules and other therapeutics to irradiated tumors. A major focus of this e-book is to elucidate immunological facets of ionizing irradiation. It is indeed becoming clear that highand low-dose irradiation elicit distinct immunological effects. Furthermore, the mode of irradiation-induced cell death (e.g., apoptosis, necrosis) has a major impact on anticancer immune responses...

introduction h istone deacetylase inhibitors (hdis), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. valproic acid (vpa) is an hdi, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. in this study, we evaluated the effects of vpa and ionizing radiatio...

Ionizing irradiation is a well‑established therapeutic modality for malignant gliomas. Due to its high cellular uptake, 5‑aminolevulinic acid (ALA) is used for fluorescence‑guided resection of malignant gliomas. We have previously shown that 5‑ALA sensitizes glioma cells to irradiation in vitro. The aim of the present study was to assess whether 5‑ALA acts as a radiosensitizer in experimental g...