1. An association has been reported between QT interval abnormalities and cardiovascular autonomic neuropathy in diabetic patients. The QT interval abnormalities reflect local inhomogeneities of ventricular recovery time and may be related to an imbalance in cardiac sympathetic innervation. Sympathetic innervation of the heart can be visualized and quantified by single-photon emission-computed ...

Meta-iodobenzylguanidine, a guanethidine analogue, is a newly synthesised substance capable of imaging the adrenal medulla. In a woman in whom phaeochromocytoma has been diagnosed iodine-131-labelled metaiodobenzylguanidine was given intravenously; gamma-camera images showed bilateral adrenal tumours and uptake corresponding to bone and liver metastases. 131I-meta-iodobenzylguanidine is effecti...

High-risk and refractory neuroblastomas carry poor overall survival, novel approaches must be explored to improve global outcome. With better knowledge of underlying molecular patterns growing radioligand portfolio, nuclear medicine physicians can test new strategies for disease assessment therapy. For decades, meta-iodobenzylguanidine (mIBG) has been used evaluate extent when coupled with iodi...

Cardiac sympathetic imaging with meta-iodobenzylguanidine (mIBG) is a noninvasive tool to risk stratify patients with heart failure (HF). In patients with ischemic and nonischemic cardiomyopathy, cardiac mIBG activity is a very powerful predictor of survival. Cardiac sympathetic imaging can help in understanding how sympathetic overactivity exerts its deleterious actions, which may result in be...

Iodinated meta-iodobenzylguanidine (MIBG) scanning is a safe non-invasive method for locating extra-adrenal paragangliomas. However, a positive result is dependent on the presence of an uptake mechanism in the tumour. We report two cases of MIBG negative intracranial catecholamine secreting tumours successfully located by selective venous sampling and nuclear magnetic resonance scanning.

Human Persistent Atrial Fibrillation Is Maintained by Rotors: The Jury Is Still Out Tomos E. Walters, MBBS; Jonathan M. Kalman, MBBS, PhD · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 517 123I-Meta-Iodobenzylguanidine Guanidine–Guided Ventricular Tachycardia Ablation: Will Expanding the Target Improve the Aim? Niti R. Aggarwal, MD; Panithaya Chareonthaitawee,...

radioiodinated meta iodobenzylguanidine (mibg) is one of the important radiopharmaceuticals in nuclear medicine. [123/131i]mibg is used for imaging of adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. for clinical application, radioiodinated mibg is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a...