background: hirschsprung disease is a complex genetic disorder of the enteric nervous system (ens), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. the definitive diagnosis of hirschsprung disease relies on histologic and/or histochemical staining of sections from suction rectal biopsies. calretinin immu...

background: peripheral nerves may be damaged during an injury and its current standard treatment is using an autologous nerve. objectives: the purpose of this experimental study is to evaluate and compare the histological results of nerve regeneration after using the eggshell membrane (esm) guidance channel with autograft. materials and methods: thirty adult male rats were divided into three ex...

Heart contains a variety of neurons known to influence cardiac functions. Little is known about the neurochemistry of these neurons. In this study, neurochemistry of intra cardiac neurons of the intrinsic cardiac ganglia was investigated. The technique used allows studying the morphology of the ganglionated nerve plexus found within the atria and great cardiac vessels as well as of individual n...

Heart contains a variety of neurons known to influence cardiac functions. Little is known about the neurochemistry of these neurons. In this study, neurochemistry of intra cardiac neurons of the intrinsic cardiac ganglia was investigated. The technique used allows studying the morphology of the ganglionated nerve plexus found within the atria and great cardiac vessels as well as of individual n...

The innervation of the digestive tract, which is known to control a wide array of functions including smooth muscle contractility, splanchnic microcirculation, epithelial cell absorption/secretion and endocrine secretion, is composed of an intrinsic component consisting of neuronal cell bodies and nerve processes of the enteric neurons (i.e., the enteric nervous system) and an extrinsic compone...

Regulation of neurite outgrowth and structural plasticity may involve the expression of intrinsic determinants controlling growth competence. We have tested this concept by targeting constitutive expression of the growth-associated protein GAP-43 to the neurons of adult transgenic mice. Such mice showed striking spontaneous nerve sprouting at the neuromuscular junction and in the terminal field...

Background: Hirschsprung disease is a complex genetic disorder of the enteric nervous system (ENS), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. The definitive diagnosis of Hirschsprung disease relies on histologic and/or histochemical staining of sections fr...

breast cancer is common and is considered second cause of cancer related mortality in females. regarding importance of breast cancer, more investigation in this field is recommended. for many years investigators believed that neoplasms were not innervated but new findings have proved otherwise. this descriptive study was carried out to compare number of nerve fibers in benign, malignant and nor...

BACKGROUND Scars can cause pain, even without symptoms of underlying nerve damage. A lack of knowledge on intrinsic scar pain hampers effective treatment of these complaints. OBJECTIVE Aggregate current knowledge on the prevalence, etiology, and pathophysiology of intrinsic pain in dermal scars. STUDY DESIGN Systematic review. SETTING University Medical Center. METHODS We searched the E...