how to cite this article: fallah r, yadegari y, salmani nodushan m. efficacy and safety of intravenous sodium valproate in convulsive status epilepticus in children in shahid sadoughi hospital. iran. j. child. neurol 2012;6(2):39-44.   objective status epilepticus (se) is the most common pediatric neurologic emergency with high mortality and morbidity. there is no consensus on the drug of choic...

BACKGROUND Status epilepticus (SE) is a serious neurological condition and requires prompt treatment. Sodium valproate has been used to treat SE successfully but its role as the first-line antiepileptic drug (AED) is still controversial. This study evaluated the efficacy of intravenous sodium valproate to determine if it is non-inferior to intravenous phenytoin in SE treatment. METHODS Patien...

Background: Status epilepticus (SE) is a serious neurological condition and requires prompt treatment. Sodium valproate has been used to treat SE successfully but its role as the first-line antiepileptic drug (AED) is still controversial. We aimed to compare the efficacy of intravenous sodium valproate and phenytoin head-to-head as the firstline AED treatment in SE. Methods: We enrolled patient...

background: status epilepticus (se) is a type of persistent lasting seizure with high mortality and morbidity. numerous medications are suggested for the treatment of se, two of which are sodium valproate and phenytoin. the purpose of this study is to conduct a comparison between the effi ciencies of intravenous sodium valproate and phenytoin in the treatment of this type of epilepsy. methods: ...

OBJECTIVE Migraine headache is a chronic and disabling condition in adults. Some studies have investigated the efficacy of sodium valproate in the treatment of acute migraine, but the effectiveness and tolerability of intravenous valproate as abortive therapy remains unclear. This study aimed to evaluate the effects of sodium valproate and dexamethasone in the treatment of acute migraine. MET...

BACKGROUND Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease. METHOD Case Studies. RESULT Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy. CONCLUSION Pathological laughter can be a side effect of intravenous sodium valproate.

BACKGROUND Despite the impact of sodium valproate and dexamethasone on migraine headache, the efficacy of the two drugs has not been properly investigated and compared. This trial compared the effect of the two drugs on acute migraine headache. METHODS This double blind randomized clinical trial was conducted on patients aged 18 to 65 years with acute migraine headache who referred to the eme...

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