Intrathecal midazolam binds with gamma aminobutyric acid-A receptors in the spinal cord leading to an analgesic effect. Clinical studies suggested that intrathecal midazolam may also reduce nausea and vomiting when used as an adjunct to other spinal medications. However, the potential neurotoxic effect of intrathecal midazolam remains a concern. This meta-analysis aims to evaluate the effective...

intrathecal administration of midazolam has been reported to have antinociceptive action, and to be an effective analgesic agent. in this prospective double-blind study we aimed to evaluate the postoperative effects of intrathecal midazolam with lidocaine following perineal operation. forty patients were randomly allocated to two groups: 20 patients in the control group received 2 ml of 5% heav...

BACKGROUND Post herpetic neuralgia is a chronic neuropathic pain syndrome which remains one of the most difficult pain disorders to treat. Epidural injection of methylprednisolone with or without local anesthetic provides relief for neuralgia for a short duration only. Recent studies have shown a promising anti nociceptive effect for intrathecal midazolam, a water soluble benzodiazepine, due to...

conclusions intrathecal midazolam 2 mg provides significantly longer and effective postoperative analgesia with no side effects. results postoperative analgesia was significantly longer in the midazolam group compared to the control group (201.5 minutes vs. 357.6 minutes). the mean onset times of the sensory and motor blocks were significantly faster (p < 0.01) in the midazolam group compared t...

aim and background:   adding new supplements when performing spinal anesthesia can increase the duration of analgesia. the aim of the present study has been to compare intrathecal midazolam and tramadol with the conventional method for postoperative pain and shivering control after elective caesarean section. methods and materials:   in this double-blind clinical trial, 210 asa class i,ii women...

BACKGROUND Anesthesia today has strived to decrease labor pain in a tolerable and controllable fashion. Intrathecal midazolam has been introduced as an adjunct to analgesics. The study was planned to assess the efficacy, safety and duration of analgesia produced by intrathecal midazolam adjunct to sufentanil in decreasing labor pain. METHODS In a randomized clinical trial 80 parturient includ...

This study investigated the possible analgesic effect of midazolam as a result of interruption of those spinal cord pathways taken by pain afferents. Experiments were performed on 15 male Wistar rats with chronically implanted lumbar subarachnoid catheters. The threshold for pain induced by brief passage of electric current between pairs of electrodes placed on the tail and the skin of the neck...

BACKGROUND A pain-free postoperative period is essential following a caesarean section so new mothers may care for and bond with their neonates. Intrathecal adjuvants are often administered during this procedure to provide significant analgesia, but they may also have bothersome side effects. Intrathecal midazolam produces effective postoperative analgesia with no significant side effects. OB...