purpose: to evaluate the results of combined chemotherapy and periocular carboplatin injection to control advanced intraocular retinoblastoma (rb). methods: in this prospective interventional case-series, we included 8 eyes of 8 patients with advanced intraocular rb (group c or d in international intraocular retinoblastoma classification, iirc). in these patients, periocular carboplatin was inj...

leiomyoma is a very rare intraocular tumor, which can occur in the iris, ciliary body and choroids. we report a case of choroidal leiomyoma in a 16-years old women whose left eye was enucleated because of clinical suspicion for melanoma. using conventional light microscopy tumor was interpreted as spindle cell tumor, most probably of neurogenic origin and after using immunohistochemical studies...

The role of the immune response in the elimination of spontaneous metastases arising from intraocular tumors was examined in a syngeneic intraocular murine tumor model. P91 mastocytoma (DBA/2 origin) expresses strong tumor-specific transplantation antigens and grows transiently in the eyes of syngeneic hosts before undergoing spontaneous rejection. An organ culture technique was used to detect ...

Allogeneic tumors, transplanted into the anterior chamber of the mouse eye, grow progressively and eventually kill the host. However, recipients that have been previously immunized to the alloantigens of the tumor are completely resistant to intracameral tumor challenge. In the present study the authors examined the role of specific immune effector elements in preventing, controlling, or eradic...

Purpose To report a patient who presented with a very late-onset new growth of intraocular retinoblastoma, which occurred 11 years after the initial combined treatment. Observations A 12-year-old monoophthalmic female patient presented with bilateral familial retinoblastoma showing new growth of intraocular tumor after 11 years of complete regression following combined local and systemic trea...

An 18-month-old Standardbred filly had a large intraocular tumor involving the optic nerve. The tumor was a malignant medulloepithelioma, a rare intraocular neoplasm derived from the primitive medullary epithelium. By light microscopy the tumor had cords and lobules of primitive neuroepithelial cells that formed clefts and true rosettes. Electron microscopy of the rosettes showed a girdle of zo...

Interference of oncogenic N-nitrosourea in intraocular tumor induction by human adenovirus type 12 in rats was examined. Transplacental administration of methylnitrosourea to rat embryo reduced significantly the latent period of the intraocular adenovirus tumor in each animal whereas in groups preadministered with ethylnitrosourea the decrease in the latent period showed marked individual varia...

Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonetheless. For example, intraocular adenovirus-induced (Ad5E1; adenovirus type 5 early region 1) tumors are rejected in syngeneic C57BL/6 mice by one of two pathways. One pathway leads to extensive necrosis of innocent bystander cells and culminates in destruction of the eye, a condition called phthisis....