purpose: to evaluate the diagnosis of intraocular tuberculosis (tb) with polymerase chain reaction (pcr) and to report 13 cases of presumed intraocular tb. methods: of 168 patients with uveitis, 13 patients (7.74%) had criteria for intraocular tb (tb group). thirteen patients with non-tb uveitis were randomly selected as the control group. samples for pcr were obtained from the aqueous humor. s...

The lack of any uniform diagnostic criteria for intraocular tuberculosis, in either immunocompetent or immunocompromised individuals, has contributed to the confusion regarding diagnosis and management. However, recent studies addressing the clinical significance of purified protein derivative test results, computerized tomography of the chest, and molecular diagnostic procedures have provided ...

Purpose To report a novel clinical sign in patients with intraocular tuberculosis. The current study is an observational consecutive case series of patients diagnosed with intraocular tuberculosis managed at a tertiary eye care centre from June 1, 2012 to December 31, 2015. Observations The diagnosis of intraocular tuberculosis was made in 6 patients based on ocular features suggestive of tub...

The pathogenesis of intraocular tuberculosis remains poorly understood partly due to the lack of adequate animal models that accurately simulate human disease. Using a recently developed model of ocular tuberculosis following aerosol infection of guinea pigs with Mycobacterium tuberculosis, we studied the microbiological, histological, and clinical features of intraocular tuberculosis infection...

The diagnosis of intraocular tuberculosis has been a challenge until the introduction of polymerase chain reaction (PCR) to detect the mycobacterial-specific DNA sequence in the intraocular fluids. Such investigations have confirmed diverse manifestations of intraocular tuberculosis including retinal vasculitis and serpiginouslike choroiditis. The latter may manifest with multifocal lesions inv...

BACKGROUND Intraocular tuberculosis is uncommon and has various clinical presentations. Lack of specific clinical clues can make the diagnosis challenging. The purpose of this study is to report a clinical presentation of tuberculous iridocyclitis that mimics phacolytic glaucoma and has a distinctive inflammatory deposit in the inner side of the cornea. This report is the first to describe the ...

OBJECTIVE To develop an animal model of intraocular tuberculosis (TB) with features of pulmonary TB and extrapulmonary dissemination to the eye. METHODS Hartley strain guinea pigs were infected via an aerosol route with virulent Mycobacterium tuberculosis. One group of guinea pigs was infected with a relatively low bacterial inoculum and received no treatment. A second group of guinea pigs re...

PURPOSE The aim of this article is to report a case of uveal tuberculoma simulating an intraocular tumor in which the diagnosis was only possible by polymerase chain reaction (PCR) analysis. METHOD This is a case report. RESULTS A36-year-old male presented with a progressive growing intraocular tumor and no history or positive test for other systemic disease. The eye eventually turned blind...