background: acute opioid overdose is a common cause of admission in emergency department. in spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. this study aimed to compare two most recommended administration modes for naloxone. methods: in this single-blind clinical trial, 80 patients with methadone overdose syndrome were ra...

nowadays nanotechnology as a new direction of science allows us to develop therapeutic methods of the endogenous intoxication syndrome and to create a new class of biocompatible sorbents. in ukraine first preparations of medical nanotechnology were produced and patented in 1998. these are ikbb (intracorporeal biocorrector), magnet-controlled sorbent (mcs-b), and micromage-b. the preparations ar...

A 55-year-old man with schizophrenia developed water intoxication due to primary polydipsia. His manner of antidiuretic hormone secretion was investigated by water loading and infusion of hypertonic saline to clarify the form of the syndrome of inappropriate antidiuretic hormone secretion. The plasma antidiuretic hormone level, which may be involved in the occurrence of water intoxication, was ...

In work on Wistar rats with experimental crush syndrome and acute alcohol intoxication shown that alterations of «metabolic profile» are stipulated by the lymphatic system, which emerges as an active component to urgent adaptation in critical situations. It is shown by the expressed infringements of an exchange of electrolytes in plasma. lymph and myocardium at the rats, that can make a part of...

Fulminant hepatic failure is a fatal complication of iron intoxication. Currently, there no well-established treatment. A 23-year-old Japanese woman, with past medical history deficiency anemia, presented fulminant caused by Multiple organ progressed despite plasma exchanges and deferoxamine therapy, she subsequently developed acute respiratory distress syndrome. Even though Venous-Venous Extra...

BACKGROUND Irrigation of closed body spaces may lead to substantial perioperative fluid and electrolyte shifts. A syndrome occurring during transurethral resection of prostate (TURP), and a similar syndrome described in women undergoing transcervical endometrial ablation (TCEA) are both characterised by a spectrum of symptoms which may range from asymptomatic hyponatraemia to convulsions, coma,...

Attentional, executive, and memory processes play a pivotal role in time perception. As acute or chronic alcohol consumption influences these processes, it should also modify We systematically reviewed critically assessed all existing studies on perception among drinkers, following the PICOS procedure PRISMA guidelines. selected 31 articles, distributed across four populations (i.e., intoxicati...

Salicylate intoxication is a very common problem in everyday clinical practice. We describe a new case of salicylate-induced reversible Fanconi's syndrome in a 28-year-old Cypriot male who ingested 50 g of acetylsalicylic acid with suicidal intent. To our knowledge, this is the second case ever described. It is suggested that clinicians should be aware of this salicylate intoxication-induced co...

Gluteal compartment syndrome is a relatively rare condition that mostly result from atraumatic causes such as prolonged immobilization due to drug abuse or alcoholic intoxication and incorrect positioning during surgical procedures rather than traumatic causes. Early diagnosis is difficult and sometimes delayed or overlooked because of poor physical signs resulting from altered mental status an...