the aim of the research work was to chemically modify guar gum(gg) as a ph sensitive co-polymer and formulating intestinal targeting eso nanoparticles (nps) using the synthesized co-polymer. poly acrylamide-grafted-guar gum (paam-g-gg) co-polymer was synthesized by free radical polymerization. chemical modification of paam-g-gg by alkaline hydrolysis results in formation of a ph-sensitive co-po...

Per oral delivery of hydrophilic drugs is one of the most challenges in biopharmaceutical research. Hydrophilic drugs show low bioavailability following oral administration because of their poor intestinal permeation. In the last few years great interest has focused on search of different intestinal permeation enhancers for the oral delivery of BCS class iii drugs, small polar molecules, vaccin...

Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposom...

OF THE THESIS ....................................................................................... ii ACKNOWLEGEMENT.................................................................................................. iv TABLE OF CONTENTS ................................................................................................. v LIST OF TABLES ..............................................

Objective: To prepare and evaluate lipid based drug delivery systems of Tacrolimus. Methods: Lipid based solid dispersion (SD) and self microemulsifying drug delivery systems (SMEDDS) of Tacrolimus are prepared and evaluated. Firstly, solid dispersions, liquid and solid self microemulsifying drug delivery systems of Tacrolimus were prepared. Prepared formulations were evaluated by dissolution t...

A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such mater...