background & aim: low back pain is the most debilitating condition, and can lead to decreased physical function, compromised quality of life, and psychological distress. several studies have been conducted to recognize the risk factors of low back pain, but despite of strong relationship between obesity and low back pain, the underlying mechanisms are unclear. the aim of this study was to evalu...

conclusions in this study, we found that in spite of previous beliefs, discopathies were not common etiologies of lbp. thus, even in patients with proven ldh by imaging studies, the physician should perform a thorough evaluation for other causes of lbp to avoid unnecessary lumbar surgeries. results in our study, among 1250 patients with proven ldh by mri, 500 patients (40%) had chronic lbp and ...

background & aim: low back pain is the most debilitating condition, and can lead to decreased physical function, compromised quality of life, and psychological distress. several studies has conducted to recognize the risk factors of lbp, but despite of strong relationship between obesity and lbp, the underlying mechanisms are unclear. the aim of this study was to evaluate the relationship betwe...

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

background & aim: low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. present therapies for intervertebral disc (ivd) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

Background: lumbar disc degeneration is a multifactorial degenerative disease which is affected by genetic inheritance and environmental factors. Type XI collagen is important for organization of the extracellular matrix and cartilage collagen construction. Rs1676486 is a SNP that causes the conversion of C-T, resulting in a change in the expression of the collagen 11 alpha chain. The T allele ...

background: a large proportion of patients presenting with lumbar disc disease are opium addicts in our region. it was, therefore, hypothesized that morphine might affect the intervertebral disc. we investigated the histological findings of morphine dependency on intervertebral discs in rat.   methods: forty nmri adult male rats (230-250 g) placed on ordinary diet and received aqueous solution ...

background: intervertebral disc herniation is a major cause of low back pain. several treatment methods are available for lumbar disc herniation including chemonucleolysis, open surgery, nucleoplasty, laser disc decompression, and intradiscal electrothermal therapy. the high prevalence of lumbar disc herniation necessitates a minimally invasive yet effective treatment method. in this study, we ...

conclusions the present data do not suggest that pregabalin is more efficacious than placebo in the treatment of lumbar and cervical radicular pain. however, the small sample size of this study may have affected the ability to detect such a difference. results data on 19 of the 39 patients recruited were available for analysis. no statistically significant differences in the pain, disability, a...