clinicians should be aware of new developments to familiarize themselves with pharmacokinetic and pharmacodynamic characteristics of new anticoagulant agents to appropriately and safely use them. for the moment, cardiologists and other clinicians also require to master currently available drugs, realizing the mechanism of action, side effects, and laboratory monitoring to measure their anticoag...

background: warfarin is an effective oral anticoagulant which exert its effect by blocking the utilization of vitamin k. warfarin therapy requires ongoing monitoring using the international normalized ratio (inr). in this study, effect of modest increase in vitamin k intake from vegetables on inr values was evaluated in warfarin treated patients. methods: a single-center study involving 24 outp...

Prothrombin time can be measured roughly on whole blood as in neonates, but is more commonly measured from plasma. Blood is taken into a vacutainer containing liquid citrate. Citrate acts as an anticoagulant by consuming all the calcium in the sample. The blood is mixed and centrifuged to separate blood cells from the plasma. The plasma is placed in a coagulation machine which takes a sample of...

Dear Madam, The P.T. assay, first described in 1935 by Quick et al. soon became the monitoring of oral anticoagulant therapy. The P.T. measures the affect of reduction in the Vit. K dependent coagulant factors II, VII and X. Because the Prothrombin Time Ratio (P.T.R.) is markedly affected by the activity of thromboplastin, the W. It helps to determine the intensity of anti-coagulation therapy b...

studies have shown that the percentage of ring sideroblasts in MDS is not prognostically important. Thus, in the revised WHO classification, a diagnosis of MDS-RS may be made even in the presence of only 5% of ring sideroblasts in cases with SF3B1 mutation. MDS-RS cases will be subdivided into cases with single lineage dysplasia (previously classified as RARS) and cases with multilineage dyspla...

fresh frozen plasma (ffp) and prothrombin complex concentrate (pcc) reverse oral anticoagulants such as warfarin. we compared the standard dosage ffp and pcc in terms of efficacy and safety for patients with mechanical heart valves undergoing interventional procedures while receiving warfarin. fifty patients were randomized (25 for each group) with mechanical heart valves [international normali...