Introduction:  IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T polymorphism. Hence, the aim of the present study was to investigate the association between IL-8-251 A/T and CXCR2 +1208 C/T genes ...

We have previously show" thai after peripheral nerve lesion the synthesis 0' NGF is induced in cells 01 the nerve sheath (Heumann el 81., 19878). Further analysis led 10 the identiflcation 01 growth factars and intracellular mechanisms responsible 10r this induction in sciatic fibroblasts (lind holm el 81., 1988; Hengerer el 81., 1990). The prese"t work aimed al the elucidation of the regulatio...