background & objective: interleukin (il)-10 is an important anti-inflammatory and immunomodulatory cytokine. some authors believe that single nucleotide polymorphisms (snp) in the promoter region of the il-10 gene have been associated with susceptibility to hiv infection and progression to aids, but its role is not clearly defined yet. the present study was undertaken to evaluate the associ...

Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both immunosuppressive and anti-angiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis...

conclusions these results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of hbv infection and susceptibility to hbv infection. results persistent hbv infection was associated with il-10-1082 ag (p = 0.001) and gg (p = 0.004) genotypes and g (p = 0.000) allele. il-10-819 t/c and -592 a/c genotype and allele frequencies did not show any correlation with the ...

Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...

the underlying mechanisms leading to the development of human t-cell lymphotropic virus type i (htlv-i) associated myelopathy/tropical spastic paraparesis (ham/tsp) in htlv-i infected individuals are not fully understood. host genetic factors appear to be involved as risk factors for developing ham/tsp. we investigated the possible contribution of interleukin-10 (il-10) as a risk factor to ham/...

ABSTRACTAim: To evaluate the effect of intra-canal cryotherapy on interleukin-1βand interleukin-10 expression in teeth with symptomatic apical periodontitis.Methodology: Forty-eight single rooted patients periodontitiswere randomly divided into 4 groups according to irrigation protocol.Group I (control); 5% sodium hypochlorite at room temperature. Group II; coldsodium (2-5°C). III; final rinse ...

This review aimed to describe the interleukins and interleukin gene polymorphisms related recommended as a RAS biomarker. Articles were searched through PubMed, ScienceDirect, Cochrane Library databases, using keywords of “Interleukin” AND “Recurrent Aphthous Stomatitis”. The Risk Bias Assessment tool for Non-randomized Studies (RoBANS) was used, writing this refers Preferred Reporting Items Sy...