The effects of interictal epileptiform discharges on neurocognitive development in children with medically-intractable epilepsy are poorly understood. Such discharges may have a deleterious effect on the brain's intrinsic connectivity networks, which reflect the organization of functional networks at rest, and in turn on neurocognitive development. Using a combined functional magnetic resonance...

Pilocarpine, a muscarinic agonist, produces status epilepticus that is associated with the later development of chronic recurrent seizures. When applied to rat hippocampal slices, pilocarpine (10 microM) produced brief (<200 ms) epileptiform discharges that resembled interictal activity that occurs between seizures, as well as more prolonged synchronous neuronal activation that lasted seconds (...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: e pilepsy is a common, chronic neurological disorder that affects more than 40 million people worldwide. epilepsy is characterized by interictal and ictal functional disturbances. the presence of interictal epileptiform discharges (ieds) can help to confirm a clinical diagnosis of epilepsy, and their location a...

The hippocampus plays an important role in the genesis of mesial temporal lobe epilepsy, and the entorhinal cortex (EC) may affect the hippocampal network activity because of the heavy interconnection between them. However, the mechanism by which the EC affects the discharge patterns and the transmission mode of epileptiform discharges within the hippocampus needs further study. Here, multielec...

BACKGROUND AND PURPOSE This study aimed to determine whether preoperative or postoperative electroencephalography (EEG) can predict surgical outcome for corpus callosotomy. METHODS We retrospectively reviewed the medical records of 16 patients enrolled. We compared postoperative seizure outcome according to seizure type, preoperative interictal EEG, preoperative ictal EEG, and postoperative i...

OBJECTIVES To present long-term outcome and to identify predictors of seizure freedom after vagus nerve stimulation (VNS). METHODS All patients who had undergone VNS implantation in the Epilepsy Centre Bethel were retrospectively reviewed. There were 144 patients who had undergone complete presurgical evaluation, including detailed clinical history, magnetic resonance imaging, and long-term v...

We previously reported that low-frequency electric cortical stimulation (LFECS) directly applied to the epileptic focus by means of subdural electrodes decreased the number of interictal epileptiform discharges in patients with intractable partial epilepsy. In the present study, LFECS was applied to the epileptic foci directly in four patients with medically intractable partial epilepsy through...

• Augmenting datasets improves the performance of neural networks for interictal epileptiform discharge detection. Time shifting and different montages can reduce need annotated data. Deep learning may cause a fundamental shift in clinical EEG analysis. Automating detection Interictal Epileptiform Discharges (IEDs) electroencephalogram (EEG) recordings time spent on visual analysis diagnosis ep...