background: parenteral nutrition (pn) is a valuable life saving intervention, which can improve the nutritional status of hospitalized malnourished patients. pn is associated with complications including hyperglycemia. this study was conducted to compare two methods of blood glucose control in traumatic brain injury patients on pn. materials and methods: a randomized, open-label, controlled tri...

introduction: hyperglycemia is a common problem encountered in hospitalized patients, especially in critically ill patients due to stress and using parenteral nutrition. uncontrolled hyperglycemia may be associated with increased infection risk. the principal benefit of intensive insulin therapy is a decrease in infection-related complications and mortality. the aim of this study was the assess...

background: we investigated the efficacy of a mobile-based  bolus advisor app in comparison with the usual multiple daily  injections (mdis) in diabetic patients. materials and methods: in a nonrandomized, controlled clinical trial, 62 diabetic patients  were selected to receive a 12-week intensive glycemic control by either a mobile-based bolus advisor (app) or mdi in the usual manner.we compa...

RATIONALE Hyperglycemia and insulin resistance have been shown to increase morbidity and mortality in severely burned patients, and glycemic control appears essential to improve clinical outcomes. However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality. OBJECTIVES To determine wheth...

BACKGROUND Hyperglycemia is associated with increased mortality in critically ill patients. Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality and increased rates of severe hypoglycemia. We conducted a meta-analysis to update the totality of evidence regarding the influence of intensive insulin therapy compared with conventional insulin therapy on mor...

BACKGROUND Intensive insulin therapy to maintain blood glucose at or below 6.11 mM reduces morbidity and mortality after cardiac surgery and morbidity in medical intensive care unit (ICU) patients. The authors investigated the clinical safety and outcome effects of intensive insulin therapy compared to conventional insulin therapy in patients receiving postoperative intensive care after neurosu...

AIM To find out the difference between intensive insulin therapy and conventional insulin therapy in influencing the increase of superoxide dismutase (SOD), decrease of cytokine production (TNF-alpha and IL-6), increase of albumin level, and occurrence of SIRS. METHODS The study design was randomized pre and post control group design involving 40 adult patients admitted to the ICU of Sanglah ...

BACKGROUND Intensive insulin therapy has been found to reduce mortality in some critically ill patients. We performed a systematic review and meta-analysis to ascertain the effect of intensive insulin therapy on the incidence of acute kidney injury (AKI) in adult critically ill patients. METHODS We searched MEDLINE, SCOPUS and the Cochrane Central Register of Controlled Trials for studies tha...