Objective: Integrons, which are highly effective in capturing, integrating and expressing gene cassettes, play an important role the dissemination of multiple antibiotic resistances. This study investigated correlations integrons uropathogenic E. coli (UPEC) with resistance, virulence phylogeny also relationships phylogroups resistance. Material Methods: Fifty UPECs isolated from uncomplicated ...

Multi-drug resistant bacteria are a public health problem associated with high morbidity and mortality globally. This increasing drug resistance has been linked to gene exchange between bacteria. Integrons systems known play significant role in the acquisition dissemination of antimicrobial genes especially Gram negative Hence, this study aims evaluate integrons members Enterobacteriaceae obtai...

BACKGROUND Integrons have a well-established role in the dissemination of resistance among Gram-negative pathogens and are thus a useful marker of antibiotic resistance. Shigellae are noteworthy for their multiple drug resistance, having gradually acquired resistance to most widely use and inexpensive antimicrobial drugs. METHODOLOGY A total of 32 Shigella strains belonging to serotypes flexn...

Integrons are powerful bacterial genetic elements that permit the expression and dissemination of antibiotic-resistance gene cassettes. They contain a promoter Pc that allows the expression of gene cassettes captured through site-specific recombination catalyzed by IntI, the integron-encoded integrase. Class 1 and 2 integrons are found in both clinical and environmental settings. The regulation...

Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons re...

OBJECTIVES To determine the occurrence and transmission of class 1, 2 and 3 integrons in multidrug-resistant or sulfamethoxazole-resistant Salmonella from human and animal sources and in Campylobacter spp. and Escherichia coli from broilers isolated in the Netherlands in 2004. METHODS PCR, restriction fragment length polymorphism (RFLP) and DNA sequencing were used to detect integrase genes a...

The aim of this study was to detect class Ⅰ, II and III integrons using multiplex PCR, and to analyze the role that these integrons play in mediating multidrug-resistant Staphylococcus aureus (SA). The sensitivity of SA to 20 types of antibiotics was examined using the K-B method. A genomic DNA extraction kit was used for extracting genomic DNA an...

The human intestinal microbiota plays a major beneficial role in immune development and resistance to pathogens. The use of antibiotics, however, can cause the spread of antibiotic resistance genes within the resident intestinal microbiota. Important vectors for this are integrons. This review therefore focuses on the integrons in non-pathogenic bacteria as a potential source for the developmen...

Integrons are mobile genetic elements that incorporate an open reading frame or gene cassettes. They have an important role in the acquisition and dissemination of antimicrobial resistance genes. Yet the occurrence of integrons carrying antimicrobial resistance genes in bacterial pathogens of pet animals is seldom addressed. The purpose of this study was to describe the incidence of class 1 and...