results the command is addpred for logistic regression models. conclusions the stata package provided herein can encourage the use of novel methods in examining predictive capacity of ever-emerging plethora of novel biomarkers. materials and methods we have written a stata command that is intended to help researchers obtain cut point-free and cut point-based net reclassification improvement ind...

conclusions herein we have described the stata package “adpredsurv” for calculation of the nam-d’agostino x2 goodness of fit test as well as cut point-free and cut point-based nri, relative and absolute idi, and survival-based regression analyses. we hope this work encourages the use of novel methods in examining predictive capacity of the emerging plethora of novel biomarkers. background a fun...

BACKGROUND The incremental prognostic value of myocardial perfusion-gated single photon emission computed tomography (MPGS) compared with exercise test has not yet been properly evaluated. METHODS AND RESULTS Five thousand six hundred seventy-two consecutive patients with known or suspected coronary disease undergoing exercise MPGS between 1997 and 2007 were included. Three-year predictive mo...

Reclassification is observed even when there is no or minimal improvement in the area under the receiver operating characteristic curve (AUC), and it is unclear whether it indicates improved clinical utility. The authors investigated total reclassification, net reclassification improvement, and integrated discrimination improvement for different DeltaAUC using empirical and simulated data. Empi...

Risk reclassification methods have become popular in the medical literature as a means of comparing risk prediction models. In this issue of the Journal, Pencina et al. (Am J Epidemiol. 2012;176(6):492-494) present further results for continuous measures of model discrimination and describe their characteristics in nested models with normally distributed variables. Measures include the change i...

BACKGROUND Cardiorespiratory fitness (fitness) is associated with cardiovascular disease (CVD) mortality. However, the extent to which fitness improves risk classification when added to traditional risk factors is unclear. METHODS AND RESULTS Fitness was measured by the Balke protocol in 66 371 subjects without prior CVD enrolled in the Cooper Center Longitudinal Study between 1970 and 2006; ...