to achieve tight glycemic control in diabetic patients, it may be necessary to introduce insulin therapy much earlier in the disease course. poor glycemic control is a risk factor for the development of diabetic complications. many patients require insulin therapy after several years of disease in order to maintain good glycemic control and prevent complications. but many patients do not receiv...

context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

background type 1 diabetes mellitus is one of the metabolic diseases that cause insulin-producing pancreatic ß cells be destroyed by immune system self-reactive t cells. recent­ly, new treatment methods have been developed including use of the stem cells, ß islet cells transplantation and gene therapy by viral and non-viral gene constructs. objectives the aim of this project was preparing the n...

abstract background: better control of blood sugar and reduction of diabetes complications through insulin therapy could convince people to choose this method. however, patients might refuse insulin therapy due to its painful injection, limitations in daily activities, and hypoglycemia. thus, insulin therapy could have both positive and negative effects on patients’ quality of life (qol). there...

background: parenteral nutrition (pn) is a valuable life saving intervention, which can improve the nutritional status of hospitalized malnourished patients. pn is associated with complications including hyperglycemia. this study was conducted to compare two methods of blood glucose control in traumatic brain injury patients on pn. materials and methods: a randomized, open-label, controlled tri...

objective: serum leptin concentration reflects the body fat mass. there is controversial reports about the insulin effect on serum leptin concentration. we wanted to examine the effect of insulin therapy on serum leptin in children with new onset type i diabetes. materials and methods: this was a cross-sectional study in children's medical center on 34 children who had new onset type i dia...

introduction: hyperglycemia is a common problem encountered in hospitalized patients, especially in critically ill patients due to stress and using parenteral nutrition. uncontrolled hyperglycemia may be associated with increased infection risk. the principal benefit of intensive insulin therapy is a decrease in infection-related complications and mortality. the aim of this study was the assess...