Inositol is usually classified as an essential vitamin for most animals, and is recognised as a part of the B-complex vitamins. Among all other inositol isomer forms, myo-inositol possesses biological activity. It is found in the brain, skeletal, heart, and main reproductive tissues and exists as a structural component of phosphatidylinositol in biological cell membranes. Myo-inositol, also act...

background: progress achieved in culture media formulations have resulted led to an improvement in maintaining the mammalian embryo in culture throughout the preimplantation and pre-attachment period. objective: the objective of this study was to evaluate the effect of various concentrations of myo-inositol during in vitro fertilization of bovine oocytes on subsequent embryo development. materi...

Introduction: Polycystic Ovary Syndrome (PCOS), an androgen hormone excess and ovarian dysfunction disorder is linked to insulin resistance, metabolic disorders, obesity. Inositol, a natural sugar compound effective in regulating levels follicle stimulating hormones. Metformin, biguanide drug which used for Type 2 Diabetes treatment controls glucose resistance. Using inositol metformin together...

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder among women of reproductive age, characterized by hormonal imbalance and insulin resistance. D-chiro-inositol, a naturally occurring inositol isomer, has been suggested as potential treatment option for PCOS. This study aimed to investigate the effects D-chiro-inositol supplementation on parameters, resistance in with Methods...

Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence at least one energetic pyrophosphate moiety on myo-inositol ring. They exist ubiquitously in eukaryotes and operate as metabolic messengers surveying phosphate homeostasis, insulin sensitivity, cellular energy charge. Owin...

We prepared [3H]inositol-,3-[32P]phosphate-and 4-[32P]phosphate-labeled inositol phosphate substrates to investigate the metabolism of inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. In crude extracts of calf brain, inositol 1,3,4-trisphosphate is first converted to inositol 3,4-bisphosphate, then the inositol 3,4-bisphosphate intermediate is further converted to inositol 3-phosphat...

The objective: to substantiate and evaluate the improvement of pre-gravida preparation in women with a history combined infertility factors. Materials methods. We examined 102 who were diagnosed two factors simultaneously – tubal origin associated anovulation caused by hyperprolactinemia polycystic ovary syndrome. All patients divided into groups according three-month regimen: 1st group (52 wom...

Polikistik over sendromu (PKOS) üreme çağındaki kadınlarda görülen bir endokrin bozukluk olup, üreme, hormonal ve metabolik anomalilere neden olur. İnsülin direncinin (İD) eşlik etmesi nedeniyle PKOS tedavisi için insülin duyarlaştırıcı özelliği bulunan farklı terapötik ajanlar da kullanılmaktadır. inositol antioksidan olan alfa lipoik asit de bu arasında yer almaktadır. İnositol (myo-inositol ...