نتایج جستجو برای: influenza agents
تعداد نتایج: 428899 فیلتر نتایج به سال:
the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...
Background: Influenza viruses are one of the most important etiological agents of res-piratory disease in humans and cause epidemics and pandemics with substantial mor-bidity and mortality worldwide. Vaccination and antiviral treatments are the sole and essential way for the prevention and control of influenza infection. During an influenza epidemic before the production of effective vaccine, a...
Introduction: The emergence and spread of the pandemic H1N1 influenza virus in 2009 indicates a limitation in the strategy to control the infection, despite a long-established vaccination programme and approved antivirals. Production the proper vaccine against influenza is difficult due to the genetic recombination of virus in the event of pandemic and co-circulation of drug-resistance variants...
prolonged cough occurs in a large proportion of the 2 million pilgrims who participate in the annual hajj in saudi arabia. there is no unique cause for pilgrims’ respiratory involvement, but several studies suggest a high incidence of influenza as a cause of the disease. to determine influenza vaccine efficacy against respiratory disease in pilgrims, we conducted two similar cohort studies on 5...
The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small molecular inhibitors play important roles in controlling pandemics while vaccines are developed. Currently, only a few drugs, which function as influ...
Background and purpose: Influenza virus is one of the most important respiratory infectious agents. Viral antigenic variations are major problems for vaccine production process. At present, many researches have focused on conserved domains of influenza virus antigenic peptides for subunit vaccine development. Hemagglutinin small subunit (HA2) and the 23 amino acid extracellular N-terminal domai...
results: of 655 samples, 69 (10.53%) had positive results for human influenza a virus, and 5 (0.7%) samples had positive results for influenza b. of those 69 samples with positive results for influenza a viruses, 45 (6.8%) were h3n2, and 24 (3.6%) were h1n1 subtypes. in this study most cases with positive results were less than 20 years. the sample positive included 49% males and 51% females. t...
The next influenza pandemic may be imminent. Because antiviral agents and vaccines will be unavailable to people in most countries, we need to determine whether other agents could offer clinical benefits. Influenza is associated with an increase in acute cardiovascular diseases, and influenza viruses induce proinflammatory cytokines. Statins are cardioprotective and have anti-inflammatory and i...
These recommendations update information on the vaccine available for controlling influenza during the 1994-95 influenza season. The recommendations supersede MMWR 1993;42(No. RR-6)1-13. Antiviral agents also have an important role in the control of influenza. Recommendations for the use of antiviral agents will be published later in 1994 as Part II of these recommendations.
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