M ethicillin-resistant Staphylococcus aureus (MRSA) first emerged as nosocomial pathogens in the early 1960s are of great concern to public health and highly reported in human clinical samples (1). There are major international concerns about rising levels of MRSA and multi-drug resistant S. aureus owing to the difficulties of treating infections and the ease with which MRSA spreads within hosp...

methicillin-resistant staphylococcus aureus (mrsa) is one of the most important agents producing nosocomial diseases in hospitalized children. then, screening of health care providers who are in direct contact with patients in hospital is necessary. the objective of this study was to investigate mrsa collected isolates for mlsb phenotypes, in particular inducible clindamycin resistance (mlsbi)....

INTRODUCTION Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. MATERIALS AND METHODS The detection of inducible clindamycin resistance was performed by D...

Methicillin-resistant Staphylococcus aureus (MRSA) infections have become common among both hospitalized and nonhospitalized patients. Optimal outpatient therapy for MRSA infections has yet to be determined, but this matter is complicated by the possibility of inducible macrolide-lincosamide-streptogramin B resistance (MLSBi). We studied the prevalence of MLSBi in community- and hospital-associ...

background clindamycin is a frequently used antimicrobial therapeutic medicine used for the treatment of skin and soft tissue infections caused by staphylococcus aureus strains. resistance to this antibiotic is either constitutive or inducible. constitutive resistance to clindamycin could be detected by standard susceptibility testing methods. inducible clindamycin resistance could not be detec...

background and objectives: macrolide, lincosamide and streptogramin b (mlsb) antimicrobial agents are widely used in the treatment of staphylococcal infection. clindamycin is the medicine of choice for some staphylococcal infections, particularly skin and soft tissues infections. erythromycin and clindamycin are two distinct classes of antimicrobial agents which inhibit protein synthesis in bac...

background and objective: the d-test is performed by placing clindamycin and erythromycin impregnated disks at a standard distance on the agar plate then looking for the flattening of inhibition zone around the clindamycin disk. a positive d-test indicates clindamycin inducible resistance and also predicts treatment failure possibility of this antibiotic in clinic. prevalence of staphylococcal ...

background and objectives: staphylococcus aureus is an important agent in hospital and community-associated infections, causing high morbidity and mortality. introduction of the new antimicrobial classes for this pathogen has been usually followed by the emergence of resistant strains through multiple mechanisms. for instance, resistance to clindamycin (cli) can be constitutive or inducible. in...