OBJECTIVE An evaluation of the effect of chlorhexidine/ketoconazole shampoo baths on the flea control efficacy of indoxacarb applied topically to dogs. METHODS AND RESULTS We randomly allocated 18 healthy mixed-breed dogs to 3 groups: shampoo only; indoxacarb treated and medicated shampoo; and indoxacarb treated but not shampooed. Indoxacarb was administered on day 0 and dogs were shampooed o...

Fitness-related costs of evolving insecticide resistance have been reported in a number of insect species, but the interplay between evolutionary adaptation to insecticide pressure and variable environmental conditions has received little attention. We provisioned nymphs from three German cockroach (Blattella germanica L.) populations, which differed in insecticide resistance, with either nutri...

Indoxacarb (DPX-MP062) is a recently introduced oxadiazine insecticide with activity against a wide range of pests, including house flies. It is metabolically decarbomethoxylated to DCJW. Selection of field collected house flies with indoxacarb produced a New York indoxacarb-resistant (NYINDR) strain with >118-fold resistance after three generations. Resistance in NYINDR could be partially over...

An evaluation of several insecticides, namely, 0.01% fipronil, 0.05% indoxacarb, and 2% boric acid in liquid bait formulations were carried out against field populations of the longlegged ant, Anoplolepis gracilipes (Fr. Smith) (Hymenoptera: Formicidae). The baits were formulated in brown cane sugar solution (50%, wt:wt) and placed in an experimental bait station. Each bait was evaluated agains...

AIM Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor 9 (TLR-9) in mice. MATERIALS AND METHODS In this study, healthy male Swiss albino mice (n=30) aging 8-10 weeks were used to evaluate TLR-9 expression in lungs of mice following indoxacarb exposure with and without lipopolysaccharide (LPS). Indoxacarb was administered orally dissolved in groundnut oil at 4 and 2 ...

Beet armyworm, Spodoptera exigua (Hübner), and fall armyworm, Spodoptera frugiperda (J. E. Smith), are occasional pests of cotton, Gossypium hirsutum (L.), and soybean, Glycine max (L.) Merrill. These insects can be difficult to control due to insecticide resistance and larval behavior on plants. The objectives of these studies were to determine the efficacy of selected insecticides against nat...

Secondary kill of the German cockroach, Blattella germanica (L)., by baits was reported to increase the overall control efficacy of bait products. However, most studies have been based on laboratory strains and small nymphs. We compared the secondary kill of four cockroach gel baits against various developmental stages of a laboratory (Jwax) and a field (Dorie) strain B. germanica. The four bai...

A laboratory study was conducted to determine the toxicity of indoxacarb and chlorantraniliprole to Eastern subterranean termites, Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae) resulting from topical applications and exposure to treated soil. Soils with varying organic matter (0.57-3.64%) and chemical characteristics were used in termiticide bioassays. Lethal dose resulting from ...

Owing to the spread of pyrethroid resistance in Anopheles gambiae s.s. (Diptera: Culicidae) and other vector mosquitoes, there is an urgent need to develop alternative insecticides to supplement the pyrethroids for malaria control. Indoxacarb is an oxadiazine insecticide initially commercialized by DuPont for control of agricultural pests. Performance against An. gambiae bearing kdr (pyrethroid...

We are reporting a case of poisoning with a non-organophosphate pesticide (indoxacarb) resulting in methemoglobinemia and seizures, and successfully treated with ventilator care and intravenous ascorbic acid. Since there are limited data concerning the human toxicity of indoxacarb, physicians in emergency rooms should be aware of this rare poison and also its clinical presentations.