sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. the injury is a result of late inflammation, which is mediated by prostaglandins. theoretically, inhibition of prostaglandins by reagents such as indomethacine could result in alleviation of clinical adverse effects. in this study, the protective effect of topically applied indomethacine against sulfur mustard toxicity w...

Sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. The injury is a result of late inflammation, which is mediated by prostaglandins. Theoretically, inhibition of prostaglandins by reagents such as indomethacine could result in alleviation of clinical adverse effects. In this study, the protective effect of topically applied indomethacine against sulfur mustard toxici...

abstract introduction: in this study the role of pge2 as an important inflammatory mediator in indomethacine and theophylline effects on joint diameter and vascular response of chronically inflamed rat knee joint to saphenous nerve stimulation was investigated. methods: inflammation was induced by intraarticular injection of 0.2 ml freund,s complete adjuvant (fca) and 3, 7, 14, 21 days post inj...

Abstract Introduction: In this study the role of PGE2 as an important inflammatory mediator in Indomethacine and Theophylline effects on joint diameter and vascular response of chronically inflamed rat knee joint to saphenous nerve stimulation was investigated. Methods: Inflammation was induced by intraarticular injection of 0.2 ml Freund,s Complete Adjuvant (FCA) and 3, 7, 14, 21 days post i...

A novel series of nine indolyl pyrazoline pharmacophore were synthesized by the reaction of hydrazine hydrate derivatives with the synthesized chalcones (C4,C5,C6). The chalcones were synthesized by the Claisen Schimdt condensation method. These pyrazoline derivatives were evaluated for anti-inflammatory activity using Carrageenan induced paw oedema method. The activity profile reveals that the...