نتایج جستجو برای: indomethacin im

تعداد نتایج: 57832  

Journal: :Canadian journal of anaesthesia = Journal canadien d'anesthesie 1993
P Morley-Forster P T Newton M J Cook

Injectable ketorolac is an effective analgesic in ambulatory surgery patients. However, no studies have compared ketorolac with other NSAIDs in this setting. The analgesic efficacy of intramuscular ketorolac, rectal indomethacin and placebo was compared in healthy women undergoing gynaecological or breast surgery as outpatients. Ninety patients received 30 mg im ketorolac, 100 mg pr indomethaci...

2009
V. B. YADAV A. V. YADAV

The aim of present study was to prepare and characterize the recrystallized agglomerates of water insoluble non steroidal anti-inflammatory drug, indomethacin (IM) with hydrophilic polymers like polyvinyl pyrrolidone (PVP),hydroxyl ethyl cellulose (HEC) and hydroxyl propyl methyl cellulose (HPMC) by using emulsion solvent diffusion (ESD) technique for enhancing the solubility, dissolution rate,...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2002
Mia Phillipson Christer Atuma Johanna Henriksnäs Lena Holm

Mucus thickness is suggested to be related to mucosal protection. We therefore investigated the importance of the removable mucous layer and epithelial bicarbonate transport in preservation of the gastric juxtamucosal pH (pH(jm)) during luminal acid. Anesthetized rats were prepared for intravital microscopy of the gastric mucosa, and pH(jm) was measured with pH-sensitive microelectrodes. The mu...

2016
Wei-Jie Xie Yong-Ping Zhang Jian Xu Xiao-Bo Sun Fang-Fang Yang

Background: in this paper, a new physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics Fu’s cupping therapy (FCT) was established and studied by in-vitro and in-vivo experiments; the penetration effect and mechanism of FCT physical penetration technology (FCT-PPT) was preliminarily discussed. Method: Indomethacin (IM) as a model d...

Journal: :The Journal of clinical investigation 1976
F R DeRubertis T V Zenser P A Craven B B Davis

The lower O2 tension and more active anerobic metabolism that pertain in the inner medulla (IM) of kidney relative to cortex (C) are well recognized, but there is no evidence that O2 availability constitutes a limiting or regulatory factor in IM metabolism or function. In the present in vitro study, we examined the effects of O2 on adenosine 3',5'-monophosphate (cAMP) metabolism in slices of ra...

2011
R. JAYAKUMAR R. L. REIS J. F. MANO

Phosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug...

Journal: :biomacromolecular journal 0
elham mozaffari department of chemistry, gorgan branch, islamic azad university, gorgan, iran elham tazikeh-lemeski department of chemistry-gorgon branch-islamic ad university-gorgan-iran ali akbar saboury institute of biochemistry and biophysics, university of tehran, tehran, iran

human serum albumin (hsa) is the most abundant protein in the blood plasma. drug binding to hsa is crucial to study the absorption, distribution, metabolism, efficiency and bioavailability of drug molecules. in this study, isothermal titration calorimetry and molecular dynamics simulation of hsa and its complex with indometacin (im) were performed to investigate thermodynamics parameters and th...

2006
Andrew Hall Craig N. Robson Ian D. Hickson Adrian L. Harris Stephen J. Proctor Alex R. Cattan

We have reported previously the isolation and characterization of a Chinese hamster ovary cell line, designated CHO-Chl1, which exhibits resistance to bifunctional nitrogen mustards while maintaining sensitivity to a range of other alkylating agents and chemotherapeutic drugs. This enhanced drug resistance is associated with a greater than 40-fold in crease in the level of expression of an alph...

2005
M. Y. Khuhawar F. M. A. Rind A. D. Rajper

Isoniazid (INH) has been quantitated after precolumn derivatization with 5-methylfuran-2-carboxaldehyde (MFA). Chromatography was performed on a 150 mm × 4.6 mm i.d. YMC-ODS column with water–methanol–tetrahydrofuran, 59:39:2 (v/v) as a mobile phase at a flow rate of 2 mL min. Detection was performed at 328 nm. By adoption of this procedure pyrazinamide (PZA) and indomethacin (IM) separated com...

Journal: :Reproductive biology and endocrinology : RB&E 2003
Francisco Gaytán Concepción Morales Carmen Bellido Esteban Tarradas José Eugenio Sánchez-Criado

We have investigated the effects of indomethacin (IM), a non-steroidal anti-inflammatory drug, and the role of prostaglandins on the accumulation of leukocytes in the rat ovary during the periovulatory period. Adult cycling rats were injected sc with 1 mg of IM in olive oil or vehicle on the morning of proestrus. Some animals were killed at 16:00 h in proestrus. On the evening (19:00 h) of proe...

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