The concept of liver transplantation is a relatively recent one. The first descriptions of liver replacement in experimental animals were published less than 25 years ago,I,2 and the first attempt at clinical liver transplantation was not made until March I, 1963.3 The pace of clinical trials remained limited until 1980, the year when the new immunosuppressive agent cyclosporine was introduced....

primary sjögren's syndrome (pss) is a common autoimmune disease involving abnormal th17 activation. the aim of the current study was to investigate the immunosuppression effect of cyclosporine a (cys a), a potent immunosuppressor on the proliferation and activation of t cells, on the activation of th17 cells. blood samples from both inactive and active pss patients as well as healthy controls w...

Peritoneal implantation metastasis of gastric cancer cells is associated with poor prognosis. Peritoneal macrophages are the most important immune cells in the abdominal cavity to control tumor metastasis. In the present study, the immunosuppressive effects of mouse forestomach cells on macrophages were examined. Conditioned medium from mouse fore...

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (PD44)1 Sep 2021PD44-05 N-CADHERIN ANTAGONISTS N-Ac-CHAVC-NH2 RESCUE IMMUNOSUPPRESS CAUSED BY PD- L1/IDO-1 IN PROSTATE Yi Sun, Jiaoti Huang, Qiang Wei, and Lu Yang SunYi Sun More articles by this author , HuangJiaoti Huang WeiQiang Wei YangLu View All Author Informationhttps://doi.org/10.1097/JU.00000000000020...

Kaposi sarcoma (KS) is the most common cancer after kidney transplantation in the Middle East countries.1 The prevalence of KS in comparison with other tumors is also quite higher in Iranian recipients.1,2 However, squamous cell carcinoma of the skin is the most common posttransplant malignancy in other reports.1,3,4 Its incidence following kidney transplantation has steadily increased due to t...

Extracts from deer bones, called nok-gol in Korean, have long been used to invigorate Qi. While neutropenia is not well detected in normal physiological condition, it could be a cause of severe problems to develop diseases such as infectious and cancerous diseases. Thus, a prevention of neutropenia in normal physiology and pathophysiological states is important for maintaining Qi and preventing...

T f i r s t success fu l human liver transplantation (LT) in the world was reported by Sir Thomas Starzl in 1967. 1 In the following years, the results of liver transplantation were poor. Complex surgical procedure and nonselective immunosuppression made patients highly vulnerable to infections and the physicians had a daunting task of balancing this with the risk of rejection. With introductio...

Autoimmune diabetes can be transferred to young, diabetes prone BB/W rats by injecting them intravenously with concanavalin A (Con A)-treated spleen cells from acute diabetic BB/W donors. This study describes the transfer of diabetes to the normal Wistar-Furth strain of rats using a similar procedure. For the successful transfer of diabetes it was necessary to immunosuppress recipient animals w...