Subcutaneous or oral administration of the polyunsaturated fatty acid linoleic acid prolongs survival of skin allografts in mice. Mice fed on a diet deficient in polyunsaturated fatty acids show a relative immunopotentiation, as indicated by accelerated skin allograft rejection and decreased incidence and rate of development of methylcholanthrene-induced tumors. These observations support the h...

sulfur mustard has been employed in chemical warfare in certain regions including iran. the short and long term biological effects of sulfur mustard contamination have been studied in both basic and clinical aspects. sulfur mustard has been shown to induce a vast array of pathological effects in affected persons. in addition to skin, lung, eyes and gastrointestinal disturbances, sulfur mustard ...

IMMU -21 a polyherbal immunomodulator effectively enhanced the immune status of animals treated with cytotoxic and immunosuppressive agents like cyclophosphamide and azathioprine. Leucopenia, lymphopenia and neutropenia in rats induced by cyclophosphamide were significantly minimized in IMMU-21 pre treated animals. IMMU-21 strengthened the host immune status against bacterial endotoxin. Cell me...

Candida albicans may immunopotentiate antibody responses in mice to antigens unrelated to the fungus. This effect occurred best with cell-associated, rather than soluble, antigens. When dead yeasts, cell walls, or a water-soluble candidal polysaccharide were used, immunopotentiation was most dramatic when the antigen and fungal materials were given concomitantly via an intraperitoneal injection...

Breast cancer was induced in female Sprague-Dawley rats by 7,12-dimethylbenz(a)anthracene. Once tumors had become established, they were treated with varying doses of the immunopotentiating drug, levamisole. Tumor growth was measured in the various dosage groups, and at 6 months after tumor induction the animals were sacrificed. Their immunological competence at this time was measured by the mi...

treated with glutaraldehyde and concanavalin A and a protein-bound polysaccharide preparation of Coriolus ver sicolor induced synergistic resistance to L1210 leukemia in BALB/c x DBA/2Cr F, mice. This effect was dependent on the dose and timing of the administration of the proteinbound polysaccharide preparation, being most effective at the time of or 1 day after the second vaccination. Induced...