In recent years, breast cancer has been the leading cause of death among women. Researchers are studies related to help with progress our understanding and exploring more efficient less toxic therapies. Increased public awareness advances in preclinical proof feasibility clinical confirmation have led earlier diagnosis novel curative Immunomodulation is an emerging treatment, which enhance immu...

In murine models of cancer, we have achieved efficient systemic activation of tumor-specific T cells by the local administration of a CTLA4-blocking antibody at low doses. Using a slow-release formulation, we could drastically lower the serum levels of the antibody, hence decreasing adverse effects and the risk of autoimmune reactions, without losing systemic efficacy.

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...

mesenchymal stem cells (mscs),as the major stem cells for cell therapy, have been studied from different aspects in pre-clinical and clinical settings for more than a decade. these cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. hence they could be used in regenerative ...

inflammatory bowel disease (ibd) is a chronic relapsing, idiopathic disorder of the gastrointestinal tract of an unknown etiology. ulcerative colitis (uc) and crohn's disease (cd) have become important health problems.â  current medical therapy of ibd has advanced dramatically with the introduction of new biologic therapies in addition to the optimization of conventional therapies that include ...

multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae), are chronic inflammatory demyelinating disorders of central nervous system (cns). while the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. one of the approaches being proposed in eae therapy is neural stem cells (nscs) trans...