purpose: to assess the histopathological and immunohistochemical features of orbital spindle cell tumors. methods: a descriptive, retrospective study was performed on 63 pathology reports on all types of orbital spindle cell tumors at the pathology department of farabi hospital between 1995 and 2005. immunohistochemistry studies for different markers, such as smooth muscle actin, desmin, s100 p...

transforming growth factor atpha (tgf-a), parathyroid hormone-tike proteins (pthlp) and oncogene p53 proteins have all been demonstrated in a variety of human tumors anil have been implicated as causes of tumor cell aggressiveness. the present study determined the existence of these peptides and their immunohistochemicat profiles in ameloblastomas. odontogenic keratocysts and dentigerous cysts ...

the investigation and determination of the significance of neovascularization in the progression of soft tissue sarcoma is currently of increasing clinical importance. microvessel density is the morphologic evidence of neoangiogenesis in the process of malignant progression of sarcomata. this brief review of the markers commonly used in clinical practice was undertaken to determine the validity...

introduction: myxofibrosarcoma was originally described as the myxoid variant of malignant fibrous histiocytoma (mfh), a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. mfh occurring in the maxillary sinus is so rare that only 23 cases have been reported. we hereby report a case of myxofibrosarcoma in the maxillary ...

background the relationship between biomarkers and imaging features is important because imaging findings can predict molecular features. objectives to investigate the relationship between clinicopathologic and radiologic factors and the immunohistochemical (ihc) profiles associated with breast cancer. patients and methods from december 2004 to september 2013, 200 patients (mean age, 56 years; ...

background : cd117 is a thyrosin kinase receptor encoded by c-kit proto-oncogene. it is expressed during normal development in some tissues and also in a subset of neoplasia especially gastrointestinal stromal tumors   (gists). treatment with thyrosin kinase inhibitors (e.g., imatinib) is useful in cd117- positive gists. the goal of this study is to investigate the expression of cd117 in glial ...

the calcifying odontogenic cyst (coc) is a rare odontogenic cyst. only 2% of all odontogenic cysts and tumors are coc. coc associated with odontoma (cocao) reported in 24% of cocs. cocao presents a greater incidence in female, with a ratio of 2 to 1. the highest incidence of cocao occurs during the second decade with a mean age of 16 years, most frequently occurring in the maxilla (61.5%). here...

the focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. for this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (dcis), was evaluated by immunohistochemical method. all specimens were microscopically classified into histologic types...

Case Description and Clinical Findings- A seven-year-old male German shepherd dog was referred to Small Animal Clinic with severe lameness (non-weight-bearing) and considerable localized proximal right humerus swelling. Radiographic study revealed severe soft tissue swelling and pathologic fracture of proximal right humerus. Immediately, the right forelimb was removed surgically and once sample...

background in surgical pathology, atypical small acinar proliferation is commonly detected in prostate biopsies. most studies on atypical small acinar proliferation have examined morphological characteristics and the utility of immunohistochemical studies.however, these resources are not available to many pathology departments. we have found that examining additional sections is a simple and in...