the increasing prevalence of chronic diseases, e.g., cardiovascular disease, diabetes and neuronal degenerative disease, present a challenge to find more effective therapies. stem cell-based therapy, including embryonic, umbilical cord blood and adult stem cells provides a rational treatment tool for regenerative medicine and has the potential to revolutionize modern therapy. however, there are...

Glycolipids are the hybrid molecules constructing with hydrophilic carbohydrate and hydrophobic chains , and show the unique physicochemical properties and bioactivities . Their carbohydrate moieties are characteristically altered in relation to cellular proliferation , differentiation and transformation, and recently , the glycolipid associated with cellular differentiation is clarified to car...

It was observed that individuals at high risk for AIDS who are exposed to domestic cats may not develop AIDS or ARC. This may be due to protection induced by the Feline Leukemia Virus which is widespread in cats and has not been demonstrated to be pathogenic for humans. Recently developed FeLV subunit vaccines have been recognised as useful models for potential human retrovirus vaccines, but th...

Glycans are part of the essential components of a cell. These compounds play a fundamental role in several physiopathological processes, including cell differentiation, adhesion, motility, signal transduction, host-pathogen interactions, tumor cell invasion, and metastasis development. Glycans are also able to exert control over the changes in tumor immunogenecity, interfering with tumor editin...

ABSTRACT Antibody therapies have become an important component in the management of malignant disease. Antibodies can block tumour growth factors or their receptors, activate immunological attack on the tumour, and are used to deliver payloads such as radioisotopes, cytotoxic drugs or toxins. Immunotoxins are a new class of antitumour agents consisting of tumour- selective ligands (generally mo...