autoimmunity and viral infections are closely associated fields, and viruses have been proposed as a likely aetiological, contributory or triggering factors of systemic autoimmune diseases. hepatitis c virus seems to be the virus usually associated with the appearance of autoimmune diseases, and the relationship between chronic hepatitis c virus infection and some autoimmune disease has been st...

objective(s):gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. in this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. materials and methods: three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (ip) for the evaluation o...

Celiac disease (CD) is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4+ Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4+ T cells wit...

treatment of severe immune thrombocytopenic purpura (itp) accompanied by life-threatening bleeding events is challenging and a combination of treatment measures should be undertaken to rapidly increase the platelet count. herein, we report a case of severe itp in a seven-year-old boy who suffered from massive bleeding which was totally unresponsive to conventional therapeutic interventions. sin...

  Chronic Inflammatory Demyelinating Polyneuropathy is an autoimmune disease with progressive and relapsing courses. The main clinical presentations are diffuse deep tendon hyporeflexia or areflexia and symmetric proximal-distal muscles weakness. Myasthenia gravis is also an immune mediated disease with fluctuating ocular and bulbar symptoms and sometimes weakness. Although both myasthenia grav...

chronic inflammatory demyelinating polyneuropathy is an autoimmune disease with progressive and relapsing courses. the main clinical presentations are diffuse deep tendon hyporeflexia or areflexia and symmetric proximal-distal muscles weakness. myasthenia gravis is also an immune mediated disease with fluctuating ocular and bulbar symptoms and sometimes weakness. although both myasthenia gravis...

the immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.however, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.mycobacterium tuberculosis (mtb) ...

Atherosclerosis is a complex inflammatory disorder of the medium and large-sized arteries. Recent experiments demonstrated that atherosclerosis is a Th1 dominant autoimmune condition, whereas Th2 cells are rarely detected within the atherosclerotic lesions. Several studies have indicated that Th2 type cytokines could be effective in the reduction and stabilization of atherosclerotic plaque. The...

celiac disease (cd) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the hla dq2 or dq8 alleles. the etiology is multifactorial involving genetic and environmental factors, immune response, and intestinal dysbiosis. the innate and acquired t-cell mediated immunity play important roles in the pathogenesis of this disease, particular...