objective: rosa damascena mill l (r. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. it also heals depression, grief, nervous stress and tension. in the present study we evaluated antidepressant-like effect of r. damascena using forced swimming test (fst). material and methods: three doses of aqueous extract (15, 60 and 90 mg/kg) was injec...

objective: rosa damascena mill l (r. damascena) is a medicinal plant mostly known in the world for its perfume. it also has beneficial effects on stress, tension and depression. in this experiment antidepressant effect of ethanolic extract of r. damascena by forced swimming test (fst) was evaluated. material and methods: animals received ethanolic extract (15, 60 and 90 mg/kg, i.p), imipramine ...

background: in some disorders such as diabetes mellitus patients can display depressive symptoms. metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. objective: current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (no) in this way, in an expe...

objective: pimpinella anisum (p. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. in this study the antidepressant-like effect of aqueous and ethanolic extracts of p. anisum fruit in mice was investigated. materials and methods: forced swimming test (fst) and tail suspension test (tst) were used to determi...

withania somnifera (ws) possess anti-inflammatory and antioxidant properties. ws preparations have a potential therapeutic role in the central nervous system (cns) related disorders in animal models. in this study, the possible protective effect of acute aqueous ws root extract on behavioral despair was explored and compared with fluoxetine, an antidepressant with selective serotonin (5-ht) reu...

In the present study, the effects of different doses of nicotine on immobility time in mice were tested. Intraperitioneal administration of low doses of nicotine (0.025 mg/kg) decreased, but higher doses (0.8 and 1 mg/kg) increased immobility time. The anti-immobility response induced by low doses of nicotine was inhibited by high doses of the D2 receptor antagonist sulpiride, the central nicot...

We studied the effects of desipramine, alprazolam, muscimol and dizocilpine (MK-801) (alone or associated with desipramine) in the forced swimming test in rats after long-lasting termination of chronic exposure to vehicle and pentylenetetrazol. Sensitisation with pentylenetetrazol was ineffective in changing immobility time in the forced swimming test compared to vehicle treatment; pentylenetet...

Effects of co-administration with the 5-HT(2) receptor antagonist LY 53857 and the antidepressant mianserin on immobility time in the forced swimming test were investigated in mice. Mianserin did not affect the immobility time at ranges from 1-10 mg/kg, although it elicited anti-immobility effects at 20 mg/kg. Co-administration of the 5-HT(2) receptor antagonist LY 53857 and a subactive dose of...

Background: In some disorders such as diabetes mellitus patients can display depressive symptoms. Metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. Objective: Current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (NO) in this way, in an expe...

Objective: Pimpinella anisum (P. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. In this study the antidepressant-like effect of aqueous and ethanolic extracts of P. anisum fruit in mice was investigated. Materials and Methods: Forced swimming test (FST) and tail suspension test (TST) were used to determ...