background: recent analyses of hospital outbreaks have documented the spread of resistance to imipenem, which is cur­rently a major problem among gram positive and gram-negative bacteria. the aim of this study was to describe the rate of gram- positive and gram-negative isolates resistance to imipenem as an antibiotic. methods: recorded files of 242 hospitalized patients with at least one sampl...

BACKGROUND Pneumonia, and particularly nosocomial (NP) and ventilator-associated pneumonias (VAP), results in high morbidity and costs. NPs in particular are likely to be caused by Pseudomonas aeruginosa (PA), ~20% of which in observational studies are resistant to imipenem. We sought to identify the burden of PA imipenem resistance in pneumonia. METHODS We conducted a systematic literature r...

background :    acinetobacter baumannii has become one of the most important causes of nosocomial infections in recent years. the organism seems to be resistant to most classes of antibiotics. carbapenems are considered the most effective drugs for treatment of these infections. however, increasing emergence of carbapenem resistant a. baumannii has become a major healthcare problem.   methods :...

conclusions our results showed the rate of effects of different risk factors on imipenem resistance. regarding the studied risk factors, appropriate programs must be set in place to control and prevent imipenem resistance in gram-negative bacteria. results of the 374 isolated, 134 were imipenem resistant, and 240 were sensitive to imipenem. the resistance rate was more common in males and in pa...

Background: Acinetobacter baumannii is one of the causes of nosocomial infections, especially in the intensive care unit. The emergence of multidrug-resistant strains of A. baumannii has caused many problems. One of the ways to handle the phenomenon of antibiotic resistance is the use of herbal medicines and their derivatives in place of or in combination with antibiotics. The aim of this study...

OBJECTIVES Previous studies have demonstrated that a combination of levofloxacin with imipenem could prevent the emergence of resistance during the treatment of susceptible Pseudomonas aeruginosa isolates in a two-compartment pharmacodynamic model of infection. In this study, the efficacy of levofloxacin/imipenem was further evaluated against a panel of characterized P. aeruginosa strains that ...

CONTEXT Multiple surveillance programmes have reported a decline in antibiotic susceptibility of P. aeruginosa. AIM Our study aimed to study the relationship between the use of antipseudomonal drugs and the development of resistance of P. aerogenosa to these drugs. SETTING AND DESIGN Our study is retrospective. It was conducted in a medical surgical intensive care unit during a five-year pe...

The characterization of AmpC-type beta-lactamases was performed in a collection of 32 clinical Pseudomonas aeruginosa isolates with intermediate susceptibility or resistance to imipenem and ceftazidime. Twenty-one out of those 32 isolates overexpressed AmpC beta-lactamase, and the MICs of ceftazidime and imipenem were reduced after cloxacillin addition. Cloning and sequencing identified 10 AmpC...

In vitro evolution was used to predict whether the IMP-1 metallo-lactamase has the potential to evolve an increased ability to confer resistance to imipenem. Screening of eight libraries containing 9.8 10 1.4 10 (mean standard error) variants per library, with an average of 1.2 mutations per variant, detected no increased resistance to imipenem. The results predict, with >99.9% confidence, that...

We investigated the mechanisms involved in imipenem resistance in 23 clinical strains of Acinetobacter baumannii. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis showed the presence of a 30-kDa protein in imipenem-intermediate A. baumannii (IIAB) and imipenem-resistant A. baumannii (IRAB) strains; this protein was almost undetectable in imipenem-susceptible A. baum...