Platelet glycoprotein lIb/Illa (GP lIb/Illa). the receptor complex for fibrinogen, has been regarded as a megakaryocyte/platelet lineage-restricted antigen. Recently. however. it has been reported that GP lIb/Illa is expressed in blood monocytes. Studies were performed to establish the origin and immunological characteristics of monocyteassociated glycoproteins lIb and lIla (GPs lIb and lIla). ...

Marrow stromal cells are thought t o regulate hematopoiesis by producing colony-stimulating factors (CSFs) and other cytokines, either constitutively or in response to mediators such as interleukin-la (IL-la) or tumor necrosis factor-a (TNFa). The mechanisms by which these inflammatory cytokines induce CSF expression in stromal cells are not fully defined. In this study, we used human marrow st...

Two monoclonal antibodies-one that blocks ristocetininduced platelet binding of von Willebrand factor to glycoprotein lb and one that blocks adenosine diphosphateinduced binding of fibrinogen to the glycoprotein llb/Illa complex-were used to assess the binding site(s) for von Willebrand factor when platelets are stimulated with thrombin or adenosine diphosphate (ADP). Neither agonist induced bi...

The cytoadhesin family consists of platelet glycoprotein (GP) lIb-Illa and the endothelial vitronectin receptor. The $ subunit (GP lIla) of these complexes expresses the alloantigen Zw (or Pl ). This alloantigen is not expressed by members of other integrin subfamilies. By using immunoprecipitation and immunoblot techniques. we found that the /9 subunit of a heterodimer. expressed by cultured h...

Human T-cell leukemia virus type I (HTLV-1)-infected T-cell lines constitutively produce high levels of interleukin-la (ILla). To analyze the mechanisms that lead t o the expression of ILla in HTLV-I-infected cell lines, we studied regulatory regions of the human IL-la promoter involved in activation of the IL-la gene. IL-la promoter constructs drive transcription of the chloramphenicol acetylt...

Objek material tulisan ini adalah salah satu puisi serial asyhadu an lā imroatan illa anti (disingkat ALIA) karya Nizar Qabbani, penyair Suriah. Bahasa bersifat konotatif, penuh tanda dan ambigu. Sehingga bahasa agak sulit dimengerti. Maka objek formal untuk memahami yang dianalalisis teori semiotik Riffaterre. Hasil analisis Riffaterre ALIA antara lain: melalui pembacaan heuristik hermeneutik ...

Ressenya de:Picazo Muntaner, Antoni (2020)Inquisició i corrupcióPalma: Illa Edicions, 125 p.ISBN 978-84-947890-8-3

With the exception of the major platelet glycoproteins llb/Illa and lb. which function as receptors for fibrinogen and von Willebrand factor, little is presently known regarding the possible role of other platelet surface proteins in mediating platelet aggregation. We report the production of a murine monoclonal antibody (AG-i ) recognizing human platelet membrane surface protein of relatively ...

Human megakaryocytes have been shown by immunofluorescent techniques to express platelet glycoprotein lIb/Illa antigen. We report evidence that megakaryocytes derived from human committed megakaryocytic progenitor cells in vitro (CFU-M) synthesize glycoproteins lIb and lIla. Nonadherent light-density human bone marrow cells were cultured in human plasma and methylcellulose using conditions that...