Background/Aims: Common genetic variation at the IL28 locus has been found to affect the response of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American and European populations, has also been found to be associated with spont...

BACKGROUND & AIMS A common genetic variation at the IL28 locus has been found to affect the response of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American, and European populations, has also been found to be associated with s...

background: the effect of il 28 b polymorphism on sustained virology response (svr) in patients with hepatitis c genotype 1 varies among races.â  multiple studies have shown that the svr is two or three times higher in patients with cc genotype compared to those with tt genotype. this study aims to assess the relationship between il 28 b polymorphism and svr in iranian patients. materials and m...

Results We assessed 21 patients with chronic HCV infection, with a male-to-female ratio of 0.6:1. The mean age was 51.4 ± 11.9 years. The mean duration of HCV infection was 5.2 ± 5.5 years (range: 0-20 years). The predominant HCV genotype was 1b (in 16 patients – data not available for 5 patients), and the predominant IL28-B genotype was CT (9 patients), followed by TT (7 patients) and CC (3 pa...

abstract: the extreme polymorphism in mhc b-f genes enables the chickens to recognize enormous numbers of foreign peptides to trigger an immune reaction. study of this genetic resources is very important and it is essential to avoid the loss of genetic variability. genetic polymorphism among arian strain, a endogenous broiler chickens in iran, was investigated. in this study pcr-sscp was carrie...

objectives in this study, the association of tgf-β1 +915g/c and -509c/t gene polymorphisms with chronic hepatitis b was evaluated in iranian patients. materials and methods a population-based case–control study was conducted in taleghani hospital, tehran. a number of 220 patients with chronic hepatitis b and the same number of healthy control subjects were designated the case and the control gr...

conclusions our study showed no correlation between rs12979860 and rs8099917 snps and chronic hbv infection. further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings. objectives this study was carried-out to investigate the association of ifnl3 gene polymorphisms (rs12979860 and rs8099917) with hbv susceptibility, in chronic hbv-infected patien...

UNLABELLED Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN. We sought to determine if the ...

Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism (nucleotide variations) w...