نتایج جستجو برای: ife

تعداد نتایج: 1381  

Journal: :Advances in wound care 2013
Makoto Senoo

SIGNIFICANCE The skin interfollicular epidermis (IFE) is an organism's first line of defense against a harmful environment and physical damage. During homeostasis and wound repair, the IFE is rejuvenated constantly by IFE stem cells (SCs) that are capable of both proliferation and differentiation. However, the identity and behavior of IFE SCs remain controversial. RECENT ADVANCES Two opposing...

2002
C. L. OLSON Gary E. Rochau Paul Pickard Stephen A. Slutz Mark S. Derzon Richard E. Olson

There are presently four driver technologies that are being developed for IFE Power Plants: these are HIF (Heavy Ion Fusion), KrF (Krypton Fluoride laser), DPSSL (Diode-Pumped Solid-State Laser), and Z-Pinches. All four types were included in the discussions at the Snowmass Fusion Summer Study in 1999 [1]. The purpose of this paper is to discuss (1) the z-pinch power plant concept, and (2) the ...

Journal: :Journal of cell science 2010
Anren Song Sara Labella Nadejda L Korneeva Brett D Keiper Eric J Aamodt Monique Zetka Robert E Rhoads

Caenorhabditis elegans expresses five family members of the translation initiation factor eIF4E whose individual physiological roles are only partially understood. We report a specific role for IFE-2 in a conserved temperature-sensitive meiotic process. ife-2 deletion mutants have severe temperature-sensitive chromosome-segregation defects. Mutant germ cells contain the normal six bivalents at ...

2015
Richard S. Mangio SarahBeth Votra David Pruyne

eIF4E plays a conserved role in initiating protein synthesis, but with multiple eIF4E isoforms present in many organisms, these proteins also adopt specialized functions. Previous RNAi studies showed that ife-3, encoding the sole canonical eIF4E isoform of Caenorhabditis elegans, is essential for viability. Using ife-3 gene mutations, we show here that it is maternal ife-3 function that is esse...

2015
Richard S. Mangio SarahBeth Votra

eIF4E plays a conserved role in initiating protein synthesis, but with multiple eIF4E isoforms present in many organisms, these proteins also adopt specialized functions. Previous RNAi studies showed that ife-3, encoding the sole canonical eIF4E isoform of Caenorhabditis elegans, is essential for viability. Using ife-3 gene mutations, we show here that it is maternal ife-3 function that is esse...

Journal: :Journal of cell science 2015
Andrew J Friday Melissa A Henderson J Kaitlin Morrison Jenna L Hoffman Brett D Keiper

Regulated mRNA translation is vital for germ cells to produce new proteins in the spatial and temporal patterns that drive gamete development. Translational control involves the de-repression of stored mRNAs and their recruitment by eukaryotic initiation factors (eIFs) to ribosomes. C. elegans expresses five eIF4Es (IFE-1-IFE-5); several have been shown to selectively recruit unique pools of mR...

Journal: :The Journal of biological chemistry 1998
M Jankowska-Anyszka B J Lamphear E J Aamodt T Harrington E Darzynkiewicz R Stolarski R E Rhoads

The rate-limiting step for cap-dependent translation initiation in eukaryotes is recruitment of mRNA to the ribosome. An early event in this process is recognition of the m7GTP-containing cap structure at the 5'-end of the mRNA by initiation factor eIF4E. In the nematode Caenorhabditis elegans, mRNAs from 70% of the genes contain a different cap structure, m32,2,7GTP. This cap structure is poor...

2010
XIAOMING HE TAO LIN YANPING LIN

Abstract. This paper is to develop immersed finite element (IFE) functions for solving second order elliptic boundary value problems with discontinuous coefficients and non-homogeneous jump conditions. These IFE functions can be formed on meshes independent of interface. Numerical examples demonstrate that these IFE functions have the usual approximation capability expected from polynomials emp...

2017
Mika Watanabe Ken Natsuga Wataru Nishie Yasuaki Kobayashi Giacomo Donati Shotaro Suzuki Yu Fujimura Tadasuke Tsukiyama Hideyuki Ujiie Satoru Shinkuma Hideki Nakamura Masamoto Murakami Michitaka Ozaki Masaharu Nagayama Fiona M Watt Hiroshi Shimizu

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wn...

Journal: :Acta biochimica Polonica 2002
Alicja Stachelska Zbigniew Wieczorek Katarzyna Ruszczyńska Ryszard Stolarski Monika Pietrzak Barry J Lamphear Robert E Rhoads Edward Darzynkiewicz Marzena Jankowska-Anyszka

Translation initiation factor eIF4E binds the m(7)G cap of eukaryotic mRNAs and mediates recruitment of mRNA to the ribosome during cap-dependent translation initiation. This event is the rate-limiting step of translation and a major target for translational control. In the nematode Caenorhabditis elegans, about 70% of genes express mRNAs with an unusual cap structure containing m(3)(2,2,7)G, w...

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